Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3904624..3905278 Replicon chromosome
Accession NZ_CP056395
Organism Citrobacter freundii strain RHBSTW-00589

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HV241_RS18360 Protein ID WP_096755799.1
Coordinates 3904624..3905031 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HV241_RS18365 Protein ID WP_096755798.1
Coordinates 3905012..3905278 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV241_RS18340 3900572..3902305 - 1734 WP_181624676.1 single-stranded-DNA-specific exonuclease RecJ -
HV241_RS18345 3902311..3903024 - 714 WP_096755802.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV241_RS18350 3903048..3903944 - 897 WP_096755801.1 site-specific tyrosine recombinase XerD -
HV241_RS18355 3904057..3904578 + 522 WP_096755800.1 flavodoxin FldB -
HV241_RS18360 3904624..3905031 - 408 WP_096755799.1 protein YgfX Toxin
HV241_RS18365 3905012..3905278 - 267 WP_096755798.1 FAD assembly factor SdhE Antitoxin
HV241_RS18370 3905535..3906515 + 981 WP_181624677.1 tRNA-modifying protein YgfZ -
HV241_RS18375 3906595..3907254 - 660 WP_096755796.1 hemolysin III family protein -
HV241_RS18380 3907418..3907729 - 312 WP_181624678.1 N(4)-acetylcytidine aminohydrolase -
HV241_RS18385 3907782..3908510 + 729 WP_115259901.1 MurR/RpiR family transcriptional regulator -
HV241_RS18390 3908631..3910064 + 1434 WP_115257538.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15935.93 Da        Isoelectric Point: 11.2851

>T163397 WP_096755799.1 NZ_CP056395:c3905031-3904624 [Citrobacter freundii]
VVQWQSDLRVSWRAQWISLLIHGLVAVLILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLRSSTGKRQHLWLAADSMDDAEWRDLRRLILQPSMQK

Download         Length: 408 bp

>T163397 NZ_CP072564:2332756-2333043 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTAAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10570.10 Da        Isoelectric Point: 5.6311

>AT163397 WP_096755798.1 NZ_CP056395:c3905278-3905012 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163397 NZ_CP072564:2332517-2332756 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References