Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2425785..2426554 Replicon chromosome
Accession NZ_CP056395
Organism Citrobacter freundii strain RHBSTW-00589

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV241_RS11750 Protein ID WP_181625347.1
Coordinates 2425785..2426267 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV241_RS11755 Protein ID WP_168246960.1
Coordinates 2426258..2426554 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV241_RS11725 2420865..2421656 - 792 WP_181625345.1 carboxymuconolactone decarboxylase family protein -
HV241_RS11730 2421929..2422978 - 1050 WP_137363299.1 NAD(P)-dependent alcohol dehydrogenase -
HV241_RS11735 2423429..2423713 + 285 Protein_2294 aldo/keto reductase -
HV241_RS11740 2423748..2424641 - 894 WP_146716824.1 LysR family transcriptional regulator -
HV241_RS11745 2424790..2425581 + 792 WP_181625346.1 SDR family oxidoreductase -
HV241_RS11750 2425785..2426267 - 483 WP_181625347.1 GNAT family N-acetyltransferase Toxin
HV241_RS11755 2426258..2426554 - 297 WP_168246960.1 DUF1778 domain-containing protein Antitoxin
HV241_RS11760 2426667..2428649 - 1983 WP_181625348.1 MBL fold metallo-hydrolase -
HV241_RS11765 2428958..2429587 - 630 WP_117342784.1 winged helix-turn-helix transcriptional regulator -
HV241_RS11770 2429867..2431054 - 1188 WP_146716827.1 outer membrane protein transport protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-148)

Antitoxin

Vibrio phage ICP1, Orf50

(17-91)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17724.35 Da        Isoelectric Point: 8.4768

>T163387 WP_181625347.1 NZ_CP056395:c2426267-2425785 [Citrobacter freundii]
MEINVTAPALLTEGHDLQPFNCGNEVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDASTQGHSFGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

>T163387 NZ_CP072563:496245-496595 [Bacillus sp. LJBV19]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11515.11 Da        Isoelectric Point: 5.8990

>AT163387 WP_168246960.1 NZ_CP056395:c2426554-2426258 [Citrobacter freundii]
MEKLMQTSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAP
VQNVEGRQRLMDVKPEWK

Download         Length: 297 bp

>AT163387 NZ_CP072563:495958-496239 [Bacillus sp. LJBV19]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References