Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4014929..4015586 Replicon chromosome
Accession NZ_CP056393
Organism Enterobacter sp. RHBSTW-00593

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag HV242_RS19200 Protein ID WP_014171514.1
Coordinates 4014929..4015339 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HV242_RS19205 Protein ID WP_003863437.1
Coordinates 4015320..4015586 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV242_RS19180 4010927..4012660 - 1734 WP_050737267.1 single-stranded-DNA-specific exonuclease RecJ -
HV242_RS19185 4012666..4013379 - 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV242_RS19190 4013403..4014299 - 897 WP_050737268.1 site-specific tyrosine recombinase XerD -
HV242_RS19195 4014401..4014922 + 522 WP_014171513.1 flavodoxin FldB -
HV242_RS19200 4014929..4015339 - 411 WP_014171514.1 protein YgfX Toxin
HV242_RS19205 4015320..4015586 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HV242_RS19210 4015881..4016861 + 981 WP_020883730.1 tRNA-modifying protein YgfZ -
HV242_RS19215 4016970..4017629 - 660 WP_014171517.1 hemolysin III family protein -
HV242_RS19220 4017896..4018627 + 732 WP_040018863.1 MurR/RpiR family transcriptional regulator -
HV242_RS19225 4018744..4020177 + 1434 WP_020883728.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T163380 WP_014171514.1 NZ_CP056393:c4015339-4014929 [Enterobacter sp. RHBSTW-00593]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T163380 NZ_CP056393:c4015339-4014929 [Enterobacter sp. RHBSTW-00593]
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGGGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT163380 WP_003863437.1 NZ_CP056393:c4015586-4015320 [Enterobacter sp. RHBSTW-00593]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT163380 NZ_CP056393:c4015586-4015320 [Enterobacter sp. RHBSTW-00593]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References