Detailed information of TA system TA163369

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 469821..470322
• Replicon: chromosome
• Accession: NZ_CP056393
• Organism: Enterobacter sp. RHBSTW-00593

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV242_RS02240
• Protein ID: WP_050737580.1
• Coordinates: 470053..470322 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HV242_RS02235
• Protein ID: WP_050737581.1
• Coordinates: 469821..470063 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV242_RS02220	465818..466558	+	741	WP_020882900.1	KDGP aldolase family protein	-
HV242_RS02225	466677..467813	+	1137	WP_050737583.1	lactonase family protein	-
HV242_RS02230	467833..469743	+	1911	WP_050737582.1	BglG family transcription antiterminator	-
HV242_RS02235	469821..470063	+	243	WP_050737581.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HV242_RS02240	470053..470322	+	270	WP_050737580.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV242_RS02245	470326..470790	-	465	WP_050737579.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HV242_RS02250	470919..473057	-	2139	WP_020885401.1	anaerobic ribonucleoside-triphosphate reductase	-
HV242_RS02255	473425..473997	-	573	WP_032681842.1	PTS sugar transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10355.17 Da
• Isoelectric Point: 10.4653

>T163369 WP_050737580.1 NZ_CP056393:470053-470322 [Enterobacter sp. RHBSTW-00593]
MTYELVFVPRAFKEWTRLGDTVKNQFKKKLANVLVTARLHGLPDCDKIKFRSQGYRLVYQVQDNVVTVCVIAIGKREKSA
VYHDVNKRL

Nucleotide

• Length: 270 bp

>T163369 NZ_CP072555:c1758931-1758398 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9115.58 Da
• Isoelectric Point: 5.1088

>AT163369 WP_050737581.1 NZ_CP056393:469821-470063 [Enterobacter sp. RHBSTW-00593]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKMVTVSDSEDELIQTVRERLANPQKGIKVRLDDL

Nucleotide

• Length: 243 bp

>AT163369 NZ_CP072555:c1759208-1758942 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA