Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3994521..3995140 Replicon chromosome
Accession NZ_CP056385
Organism Klebsiella pneumoniae strain RHBSTW-00610

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV247_RS19745 Protein ID WP_002892050.1
Coordinates 3994922..3995140 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HV247_RS19740 Protein ID WP_002892066.1
Coordinates 3994521..3994895 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV247_RS19730 3989673..3990866 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV247_RS19735 3990889..3994035 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HV247_RS19740 3994521..3994895 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HV247_RS19745 3994922..3995140 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV247_RS19750 3995299..3995865 + 567 WP_002892030.1 maltose O-acetyltransferase -
HV247_RS19755 3995837..3995977 - 141 WP_004147370.1 hypothetical protein -
HV247_RS19760 3995998..3996468 + 471 WP_002892026.1 YlaC family protein -
HV247_RS19765 3996443..3997894 - 1452 WP_032424657.1 PLP-dependent aminotransferase family protein -
HV247_RS19770 3997994..3998692 + 699 WP_025861660.1 GNAT family N-acetyltransferase -
HV247_RS19775 3998689..3998829 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HV247_RS19780 3998829..3999092 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T163360 WP_002892050.1 NZ_CP056385:3994922-3995140 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T163360 NZ_CP072550:c237651-237331 [Acinetobacter lwoffii]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGCA
AGATCTTTTGGTACAGCCTGATAGAGGTGACCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGTGGGATACGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTAAAAGATAATTTAACAGATAAGGAAACCGCCATTCTGCACCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT163360 WP_002892066.1 NZ_CP056385:3994521-3994895 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT163360 NZ_CP072550:c237338-237066 [Acinetobacter lwoffii]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAAGTTAAAGCAAG
CCGAGTTACAGAACTCGAATTGCCTGATATTAAAGAAGTACGTGAAAAAACTGGCTTGAGCCAAAATGAATTTGCTGCAC
GTCTACATATTAGCCCCCGTACCCTGCAAAATTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTGATT
CGAATTTTAGATGCTCACCCAAGCCTTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References