Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2553706..2555294 Replicon chromosome
Accession NZ_CP056385
Organism Klebsiella pneumoniae strain RHBSTW-00610

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag HV247_RS12520 Protein ID WP_004199851.1
Coordinates 2553706..2555028 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HV247_RS12525 Protein ID WP_002904790.1
Coordinates 2555028..2555294 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV247_RS12505 2548771..2551272 + 2502 WP_032424960.1 fimbrial biogenesis outer membrane usher protein -
HV247_RS12510 2551260..2552264 + 1005 WP_023286423.1 type 1 fimbrial protein -
HV247_RS12515 2552397..2553689 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HV247_RS12520 2553706..2555028 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
HV247_RS12525 2555028..2555294 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HV247_RS12530 2555559..2555885 - 327 WP_002904788.1 hydroxyisourate hydrolase -
HV247_RS12535 2555882..2556382 - 501 WP_023286422.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HV247_RS12540 2556360..2557739 - 1380 WP_004184021.1 purine permease -
HV247_RS12545 2558085..2559239 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HV247_RS12550 2559220..2560143 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T163359 WP_004199851.1 NZ_CP056385:c2555028-2553706 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T163359 NZ_CP072549:c1755969-1755583 [Acinetobacter lwoffii]
ATGGATAATCGTTGCTTTAAGCTGAAACGCAGTCTGTGTGCATTGGCGTTTCAGCTTTTTATTTTTGCACTGCTGATGTA
TCTGTTGTATCAGTTATTACCGATTGCACTTTGGGCAGTGTGTGCTGTCATAGGCTTGGTGATTTATCAGCTGTTTTACC
GCAAGACACCACAGATTGAGCAGTTTGAATATCTGGATGGACGCGAATGGTCATTGACCGCCAAAGCACGGCCGACCCGT
CGGGTATGTATTAGTCACGTGATTGATCATCAGGCGTATATTGTGGTGTATTTCCAGCATGCCAAGGCGCGACCTTTATT
GATCTGGTGTGATCAATTGCCCTTCAAACAATGGAAATCCTTAAAATTATTGACTAAATTAATTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT163359 WP_002904790.1 NZ_CP056385:c2555294-2555028 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT163359 NZ_CP072549:c1756219-1755962 [Acinetobacter lwoffii]
ATGACTGATGACATCAGCTTAGAAGAGCGCAAAGTGATTTATCGTGCGCGTCGTGGTCTAAAAGAACTGGATGTATATTT
TGATCCCTACGTAAAAAACCATTACCTGAATGCCGAGCCTTTCGAAAAACAGATGTTTGCAGAGCTGGTTGAGCAGGAAG
ACCCGGATTTGCTGGACTGGTTTATGGAAGTGTCTGAGCCACCGCGTCCTGAACTGAAAGATTTTATCAAGAAGCTTAAA
TTTTACGTTCATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References