Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 789163..789820 Replicon chromosome
Accession NZ_CP056385
Organism Klebsiella pneumoniae strain RHBSTW-00610

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HV247_RS03940 Protein ID WP_002916310.1
Coordinates 789410..789820 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HV247_RS03935 Protein ID WP_002916312.1
Coordinates 789163..789429 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV247_RS03910 784319..785752 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
HV247_RS03915 785871..786599 - 729 WP_023342613.1 MurR/RpiR family transcriptional regulator -
HV247_RS03920 786649..786960 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HV247_RS03925 787124..787783 + 660 WP_002916317.1 hemolysin III family protein -
HV247_RS03930 787934..788917 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HV247_RS03935 789163..789429 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HV247_RS03940 789410..789820 + 411 WP_002916310.1 protein YgfX Toxin
HV247_RS03945 789827..790348 - 522 WP_002916308.1 flavodoxin FldB -
HV247_RS03950 790449..791345 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HV247_RS03955 791368..792081 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV247_RS03960 792087..793820 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T163350 WP_002916310.1 NZ_CP056385:789410-789820 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T163350 NZ_CP072539:c4359008-4358658 [Escherichia coli O128ac:H12]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT163350 WP_002916312.1 NZ_CP056385:789163-789429 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163350 NZ_CP072539:c4359253-4359002 [Escherichia coli O128ac:H12]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References