Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 129191..129717 Replicon plasmid pRHBSTW-00636_3
Accession NZ_CP056374
Organism Klebsiella pneumoniae strain RHBSTW-00636

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HV253_RS27840 Protein ID WP_000323025.1
Coordinates 129191..129478 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag HV253_RS27845 Protein ID WP_004196370.1
Coordinates 129478..129717 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV253_RS27810 124862..125179 - 318 WP_015065519.1 hypothetical protein -
HV253_RS27815 125194..125544 - 351 WP_032425551.1 hypothetical protein -
HV253_RS27820 125541..125813 - 273 WP_032425552.1 hypothetical protein -
HV253_RS27825 126669..127781 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -
HV253_RS27830 127860..128018 - 159 WP_014343509.1 type I toxin-antitoxin system Hok family toxin -
HV253_RS27835 128090..129124 + 1035 Protein_137 IS481-like element ISKpn28 family transposase -
HV253_RS27840 129191..129478 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HV253_RS27845 129478..129717 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HV253_RS27850 129968..130333 + 366 WP_009651956.1 hypothetical protein -
HV253_RS27855 130377..131114 + 738 WP_008460272.1 HupE/UreJ family protein -
HV253_RS27860 131128..131817 + 690 WP_004196322.1 hypothetical protein -
HV253_RS27865 131848..133224 - 1377 Protein_143 chromate efflux transporter -
HV253_RS27870 133181..134158 - 978 WP_004196334.1 chromate resistance protein -
HV253_RS27875 134188..134380 + 193 Protein_145 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..171701 171701


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T163348 WP_000323025.1 NZ_CP056374:c129478-129191 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T163348 NZ_CP072539:c4181087-4180773 [Escherichia coli O128ac:H12]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT163348 WP_004196370.1 NZ_CP056374:c129717-129478 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT163348 NZ_CP072539:c4181323-4181090 [Escherichia coli O128ac:H12]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References