Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 101371..102107 Replicon plasmid pRHBSTW-00636_2
Accession NZ_CP056373
Organism Klebsiella pneumoniae strain RHBSTW-00636

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag HV253_RS26620 Protein ID WP_004098919.1
Coordinates 101371..101853 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A455TK27
Locus tag HV253_RS26625 Protein ID WP_020804426.1
Coordinates 101841..102107 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV253_RS26605 97470..98870 - 1401 WP_000996654.1 ISNCY family transposase -
HV253_RS26610 99106..99738 + 633 WP_001567369.1 hypothetical protein -
HV253_RS26615 99767..101170 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
HV253_RS26620 101371..101853 - 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
HV253_RS26625 101841..102107 - 267 WP_020804426.1 DUF1778 domain-containing protein Antitoxin
HV253_RS26630 102283..102537 - 255 WP_032425571.1 hypothetical protein -
HV253_RS26635 102613..102870 - 258 WP_004098928.1 hypothetical protein -
HV253_RS26640 102919..103122 - 204 WP_004150739.1 hemolysin expression modulator Hha -
HV253_RS26645 103183..103677 - 495 WP_016528789.1 hypothetical protein -
HV253_RS26650 103708..104274 - 567 WP_042922197.1 hypothetical protein -
HV253_RS26655 104271..104534 - 264 WP_004118691.1 hypothetical protein -
HV253_RS26660 104848..105027 + 180 WP_004118349.1 type II toxin-antitoxin system ParD family antitoxin -
HV253_RS26665 105014..105112 + 99 WP_004118688.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ 1..193688 193688
- inside IScluster/Tn - - 97470..107501 10031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T163346 WP_004098919.1 NZ_CP056373:c101853-101371 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T163346 NZ_CP072539:3921618-3921959 [Escherichia coli O128ac:H12]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGCGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCCCCTTATCTCCGGGCTGTAGACATTCTGCGAGCACGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10124.47 Da        Isoelectric Point: 4.3108

>AT163346 WP_020804426.1 NZ_CP056373:c102107-101841 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINELL
ARKPQWDV

Download         Length: 267 bp

>AT163346 NZ_CP072539:3921280-3921597 [Escherichia coli O128ac:H12]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGCTATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAGGGTAACCGACT
GCACTATCTGGCTGACAGGGCCAGCATCACCGGCAGGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATGCCCGC
ACTTTATCCGCCATATGGAGTCGATGCTAACCACCGGTGAACTCAGTCCCCAACACGCCCACTGCGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A455TK27

References