Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3987091..3987710 Replicon chromosome
Accession NZ_CP056372
Organism Klebsiella pneumoniae strain RHBSTW-00636

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV253_RS19750 Protein ID WP_002892050.1
Coordinates 3987492..3987710 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HV253_RS19745 Protein ID WP_002892066.1
Coordinates 3987091..3987465 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV253_RS19735 3982243..3983436 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV253_RS19740 3983459..3986605 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HV253_RS19745 3987091..3987465 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HV253_RS19750 3987492..3987710 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV253_RS19755 3987869..3988435 + 567 WP_002892030.1 maltose O-acetyltransferase -
HV253_RS19760 3988407..3988547 - 141 WP_064147182.1 hypothetical protein -
HV253_RS19765 3988568..3989038 + 471 WP_002892026.1 YlaC family protein -
HV253_RS19770 3989013..3990464 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HV253_RS19775 3990565..3991263 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HV253_RS19780 3991260..3991400 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HV253_RS19785 3991400..3991663 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T163339 WP_002892050.1 NZ_CP056372:3987492-3987710 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T163339 NZ_CP072539:2236206-2236309 [Escherichia coli O128ac:H12]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT163339 WP_002892066.1 NZ_CP056372:3987091-3987465 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT163339 NZ_CP072539:c2236347-2236076 [Escherichia coli O128ac:H12]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References