Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2616735..2618323 Replicon chromosome
Accession NZ_CP056372
Organism Klebsiella pneumoniae strain RHBSTW-00636

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HV253_RS12905 Protein ID WP_064159736.1
Coordinates 2616735..2618057 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HV253_RS12910 Protein ID WP_002904790.1
Coordinates 2618057..2618323 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV253_RS12890 2611794..2614292 + 2499 WP_064159737.1 fimbrial biogenesis outer membrane usher protein -
HV253_RS12895 2614280..2615284 + 1005 WP_048337093.1 type 1 fimbrial protein -
HV253_RS12900 2615426..2616718 + 1293 WP_064145447.1 glycoside hydrolase family 10 protein -
HV253_RS12905 2616735..2618057 - 1323 WP_064159736.1 type II toxin-antitoxin system HipA family toxin Toxin
HV253_RS12910 2618057..2618323 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HV253_RS12915 2618588..2618914 - 327 WP_002904788.1 hydroxyisourate hydrolase -
HV253_RS12920 2618911..2619411 - 501 WP_023285113.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HV253_RS12925 2619389..2620768 - 1380 WP_004184021.1 purine permease -
HV253_RS12930 2621114..2622268 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HV253_RS12935 2622249..2623172 - 924 WP_064159735.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(149-402)

Antitoxin

(16-65)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 49187.51 Da        Isoelectric Point: 7.5357

>T163338 WP_064159736.1 NZ_CP056372:c2618057-2616735 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSLRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T163338 NZ_CP072539:2004500-2004754 [Escherichia coli O128ac:H12]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT163338 WP_002904790.1 NZ_CP056372:c2618323-2618057 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT163338 NZ_CP072539:2004252-2004503 [Escherichia coli O128ac:H12]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References