Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 849324..849978 Replicon chromosome
Accession NZ_CP056365
Organism Citrobacter freundii strain RHBSTW-00658

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag HV257_RS04150 Protein ID WP_003026936.1
Coordinates 849571..849978 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag HV257_RS04145 Protein ID WP_003026938.1
Coordinates 849324..849590 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV257_RS04120 844525..845958 - 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -
HV257_RS04125 846079..846807 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
HV257_RS04130 846860..847171 + 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
HV257_RS04135 847334..847993 + 660 WP_003838267.1 hemolysin III family protein -
HV257_RS04140 848087..849067 - 981 WP_003026944.1 tRNA-modifying protein YgfZ -
HV257_RS04145 849324..849590 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
HV257_RS04150 849571..849978 + 408 WP_003026936.1 protein YgfX Toxin
HV257_RS04155 850023..850544 - 522 WP_003026933.1 flavodoxin FldB -
HV257_RS04160 850658..851554 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
HV257_RS04165 851578..852291 + 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV257_RS04170 852297..854030 + 1734 WP_044700800.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T163311 WP_003026936.1 NZ_CP056365:849571-849978 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T163311 NZ_CP072521:c739305-739006 [Burkholderia seminalis]
ATGGACAAGATCCGCACCCGGCCGTGGGATTCGGCCGAACCCCTGAAAACCGAAGACGACATGGCCGACTACTTCGAGGC
CTGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCACGCGCTCGGCGTGATCGCACGCGCACGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGCCTGTCGCGCGAAGGGTTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTCGGCCTGCAGCTGCACGGCGCGAAAGCGCACGCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT163311 WP_003026938.1 NZ_CP056365:849324-849590 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163311 NZ_CP072521:c739647-739309 [Burkholderia seminalis]
ATGGTTGGCATACTGCCATCGGCGCCCTACCGTGCGCCTACGTTCAGCATCCGAACCACCGACGTCTTCGACGCCTGGTT
TGCCGGCCTGCAGGATCGCGTCGCGAAGCGCCGCATCCAGGCACGCATCGACTGCCTGTCGATGGGCAACCCCGGCGACT
GGAAGGCCGCCGGCTCGCCGGTCGTCGAAATGCGGATCGACCATGGCCCCGGCTATCGCGTCTACTCCGTCCGGCGCGGA
CCGATCCGGGTCATCCTGCGCTGCGGCGGCGATCAATCGACGCAACAGGCCGACATACGCGCCGCGCACGCGATGCTCGC
GCGCCTCGACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References