Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4705621..4706137 Replicon chromosome
Accession NZ_CP056329
Organism Klebsiella pneumoniae strain RHBSTW-00807

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag HV282_RS23115 Protein ID WP_009309309.1
Coordinates 4705621..4705905 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HV282_RS23120 Protein ID WP_002886901.1
Coordinates 4705895..4706137 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV282_RS23090 4701016..4701324 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
HV282_RS23095 4701409..4701582 + 174 WP_002886906.1 hypothetical protein -
HV282_RS23100 4701585..4702328 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HV282_RS23105 4702685..4704823 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HV282_RS23110 4705153..4705617 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HV282_RS23115 4705621..4705905 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV282_RS23120 4705895..4706137 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV282_RS23125 4706215..4708125 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HV282_RS23130 4708148..4709302 - 1155 WP_023159544.1 lactonase family protein -
HV282_RS23135 4709369..4710109 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T163305 WP_009309309.1 NZ_CP056329:c4705905-4705621 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T163305 NZ_CP072515:c4741588-4741220 [Klebsiella quasipneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATTACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCGGACTTCGTCGGCATGACCGTCGAGGCGGC
TGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT163305 WP_002886901.1 NZ_CP056329:c4706137-4705895 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT163305 NZ_CP072515:c4741806-4741585 [Klebsiella quasipneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGACAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCGGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATAGATG
ATGAGTTCGCGGCAATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References