Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4655993..4656659 Replicon chromosome
Accession NZ_CP056314
Organism Citrobacter freundii strain RHBSTW-00830

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag HV290_RS22185 Protein ID WP_086529694.1
Coordinates 4656300..4656659 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag HV290_RS22180 Protein ID WP_049016184.1
Coordinates 4655993..4656310 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV290_RS22140 4651281..4652105 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HV290_RS22145 4652173..4653396 + 1224 WP_003841404.1 L-sorbose 1-phosphate reductase -
HV290_RS22150 4653398..4654210 + 813 WP_032948295.1 shikimate 5-dehydrogenase -
HV290_RS22155 4654244..4654561 - 318 WP_086529692.1 CcdB family protein -
HV290_RS22160 4654561..4654854 - 294 WP_003844689.1 type II toxin-antitoxin system CcdA family antitoxin -
HV290_RS22165 4654951..4655316 - 366 WP_086529693.1 hypothetical protein -
HV290_RS22170 4655448..4655621 + 174 WP_032938222.1 hypothetical protein -
HV290_RS22175 4655692..4655853 + 162 WP_003841416.1 phage protein -
HV290_RS22180 4655993..4656310 - 318 WP_049016184.1 helix-turn-helix domain-containing protein Antitoxin
HV290_RS22185 4656300..4656659 - 360 WP_086529694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV290_RS22190 4656873..4657562 + 690 WP_086529695.1 dipeptidase PepE -
HV290_RS22195 4657628..4659259 - 1632 WP_086529696.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13422.52 Da        Isoelectric Point: 10.2555

>T163288 WP_086529694.1 NZ_CP056314:c4656659-4656300 [Citrobacter freundii]
MTKPLYWVGQARKDLLAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGSAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVI

Download         Length: 360 bp

>T163288 NZ_CP072496:c1879457-1879041 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGGGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCACCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTACCGGGCCTGGTGCTGG
AAGACTGGGTAAAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11474.35 Da        Isoelectric Point: 8.9375

>AT163288 WP_049016184.1 NZ_CP056314:c4656310-4655993 [Citrobacter freundii]
MSYEVEASSGNVYVDLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNTSGKLKVKFG

Download         Length: 318 bp

>AT163288 NZ_CP072496:c1879684-1879454 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGTGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References