Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4401411..4401927 Replicon chromosome
Accession NZ_CP056314
Organism Citrobacter freundii strain RHBSTW-00830

Toxin (Protein)


Gene name relE Uniprot ID A0A0J1MTE6
Locus tag HV290_RS20960 Protein ID WP_016149473.1
Coordinates 4401411..4401695 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag HV290_RS20965 Protein ID WP_003839576.1
Coordinates 4401685..4401927 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV290_RS20945 4397736..4398320 + 585 WP_003839584.1 fructose PTS transporter subunit IIA -
HV290_RS20950 4398698..4400836 + 2139 WP_086529648.1 anaerobic ribonucleoside-triphosphate reductase -
HV290_RS20955 4400943..4401407 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HV290_RS20960 4401411..4401695 - 285 WP_016149473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV290_RS20965 4401685..4401927 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV290_RS20970 4402005..4403918 - 1914 WP_086529649.1 BglG family transcription antiterminator -
HV290_RS20975 4403940..4404680 - 741 WP_003025772.1 KDGP aldolase family protein -
HV290_RS20980 4404677..4405795 - 1119 WP_086529650.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
HV290_RS20985 4405779..4406912 - 1134 WP_016149471.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10878.73 Da        Isoelectric Point: 10.0482

>T163286 WP_016149473.1 NZ_CP056314:c4401695-4401411 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

>T163286 NZ_CP072496:354872-355219 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT163286 WP_003839576.1 NZ_CP056314:c4401927-4401685 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT163286 NZ_CP072496:355219-355518 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MTE6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References