Detailed information of TA system TA163265

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4900554..4901070
• Replicon: chromosome
• Accession: NZ_CP056307
• Organism: Klebsiella pneumoniae strain RHBSTW-00832

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A085DK79
• Locus tag: HV292_RS24300
• Protein ID: WP_009309309.1
• Coordinates: 4900554..4900838 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HV292_RS24305
• Protein ID: WP_009309310.1
• Coordinates: 4900828..4901070 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV292_RS24275	4895949..4896257	-	309	WP_004178377.1	PTS sugar transporter subunit IIB	-
HV292_RS24280	4896342..4896515	+	174	WP_032408826.1	hypothetical protein	-
HV292_RS24285	4896518..4897261	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
HV292_RS24290	4897618..4899756	+	2139	WP_009309308.1	anaerobic ribonucleoside-triphosphate reductase	-
HV292_RS24295	4900086..4900550	+	465	WP_004192393.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HV292_RS24300	4900554..4900838	-	285	WP_009309309.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV292_RS24305	4900828..4901070	-	243	WP_009309310.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HV292_RS24310	4901148..4903058	-	1911	WP_009309311.1	BglG family transcription antiterminator	-
HV292_RS24315	4903081..4904235	-	1155	WP_009309312.1	lactonase family protein	-
HV292_RS24320	4904302..4905042	-	741	WP_009309313.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11141.99 Da
• Isoelectric Point: 10.3787

>T163265 WP_009309309.1 NZ_CP056307:c4900838-4900554 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T163265 NZ_CP072492:c4037238-4037020 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9067.60 Da
• Isoelectric Point: 8.5547

>AT163265 WP_009309310.1 NZ_CP056307:c4901070-4900828 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLHDL

Nucleotide

• Length: 243 bp

>AT163265 NZ_CP072492:c4037639-4037265 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATACCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: A0A085DK79