Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4598783..4599299 Replicon chromosome
Accession NZ_CP056297
Organism Klebsiella pneumoniae strain RHBSTW-00852

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HV298_RS22320 Protein ID WP_002886902.1
Coordinates 4598783..4599067 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HV298_RS22325 Protein ID WP_002886901.1
Coordinates 4599057..4599299 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV298_RS22295 4594267..4594575 - 309 WP_004186703.1 PTS sugar transporter subunit IIB -
HV298_RS22300 4594660..4594833 + 174 WP_064146140.1 hypothetical protein -
HV298_RS22305 4594836..4595579 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HV298_RS22310 4595936..4598074 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HV298_RS22315 4598315..4598779 + 465 WP_181486657.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HV298_RS22320 4598783..4599067 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV298_RS22325 4599057..4599299 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV298_RS22330 4599377..4601287 - 1911 WP_050886148.1 BglG family transcription antiterminator -
HV298_RS22335 4601310..4602464 - 1155 WP_032103419.1 lactonase family protein -
HV298_RS22340 4602531..4603271 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T163225 WP_002886902.1 NZ_CP056297:c4599067-4598783 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T163225 NZ_CP072460:4510431-4510778 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT163225 WP_002886901.1 NZ_CP056297:c4599299-4599057 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT163225 NZ_CP072460:4510778-4511077 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATGGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References