Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 34424..35334 Replicon plasmid pRHBSTW-00867_2
Accession NZ_CP056276
Organism Klebsiella pneumoniae strain RHBSTW-00867

Toxin (Protein)


Gene name - Uniprot ID A0A5Q9LR54
Locus tag HV307_RS25585 Protein ID WP_004181896.1
Coordinates 34864..35334 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag HV307_RS25580 Protein ID WP_004181895.1
Coordinates 34424..34867 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV307_RS25560 31489..31704 - 216 Protein_41 IS200/IS605 family transposase -
HV307_RS25565 31706..32275 + 570 Protein_42 IS200/IS605 family element transposase accessory protein TnpB -
HV307_RS25570 32630..33052 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
HV307_RS25575 33052..34323 + 1272 WP_108430166.1 translesion error-prone DNA polymerase V subunit UmuC -
HV307_RS25580 34424..34867 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
HV307_RS25585 34864..35334 + 471 WP_004181896.1 RES family NAD+ phosphorylase Toxin
HV307_RS25590 35444..35704 - 261 WP_004026352.1 hypothetical protein -
HV307_RS25595 36427..36585 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
HV307_RS25600 37188..38162 + 975 WP_004181899.1 hypothetical protein -
HV307_RS25605 38360..38737 - 378 WP_060589151.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..248629 248629
- flank IS/Tn - - 31889..32275 386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17549.81 Da        Isoelectric Point: 4.6155

>T163207 WP_004181896.1 NZ_CP056276:34864-35334 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T163207 NZ_CP072456:c3921172-3920855 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGTCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT163207 WP_004181895.1 NZ_CP056276:34424-34867 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT163207 NZ_CP072456:c3920862-3920575 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACGTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LR54

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References