Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3935627..3936246 Replicon chromosome
Accession NZ_CP056275
Organism Klebsiella pneumoniae strain RHBSTW-00867

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV307_RS19375 Protein ID WP_002892050.1
Coordinates 3936028..3936246 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HV307_RS19370 Protein ID WP_002892066.1
Coordinates 3935627..3936001 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV307_RS19360 3930779..3931972 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV307_RS19365 3931995..3935141 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HV307_RS19370 3935627..3936001 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HV307_RS19375 3936028..3936246 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV307_RS19380 3936405..3936971 + 567 WP_002892030.1 maltose O-acetyltransferase -
HV307_RS19385 3936943..3937083 - 141 WP_004147370.1 hypothetical protein -
HV307_RS19390 3937104..3937574 + 471 WP_002892026.1 YlaC family protein -
HV307_RS19395 3937549..3939000 - 1452 WP_023302231.1 PLP-dependent aminotransferase family protein -
HV307_RS19400 3939101..3939799 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HV307_RS19405 3939796..3939936 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HV307_RS19410 3939936..3940199 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T163202 WP_002892050.1 NZ_CP056275:3936028-3936246 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T163202 NZ_CP072456:713611-713988 [Klebsiella pneumoniae]
ATGAAAACATTACCTGACACATACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGTGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT163202 WP_002892066.1 NZ_CP056275:3935627-3936001 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT163202 NZ_CP072456:713191-713565 [Klebsiella pneumoniae]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGTGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTATCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTATATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References