Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4784721..4786359 Replicon chromosome
Accession NZ_CP056260
Organism Klebsiella aerogenes strain RHBSTW-00898

Toxin (Protein)


Gene name hipA Uniprot ID A0A7U9APU8
Locus tag HV316_RS23105 Protein ID WP_001314390.1
Coordinates 4784721..4786049 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A754E9C8
Locus tag HV316_RS23110 Protein ID WP_001314389.1
Coordinates 4786054..4786359 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV316_RS23085 4780698..4782182 + 1485 WP_001060567.1 chromosome partitioning protein ParB -
HV316_RS23090 4782166..4782705 + 540 WP_000938043.1 DUF2857 domain-containing protein -
HV316_RS23095 4782724..4783857 + 1134 WP_015368501.1 helix-turn-helix domain-containing protein -
HV316_RS23100 4783923..4784594 - 672 WP_000863683.1 hypothetical protein -
HV316_RS23105 4784721..4786049 - 1329 WP_001314390.1 type II toxin-antitoxin system HipA family toxin Toxin
HV316_RS23110 4786054..4786359 - 306 WP_001314389.1 helix-turn-helix transcriptional regulator Antitoxin
HV316_RS23115 4786910..4789222 + 2313 WP_015368502.1 autotransporter outer membrane beta-barrel domain-containing protein -
HV316_RS23120 4789329..4789922 + 594 WP_015368503.1 hypothetical protein -
HV316_RS23125 4790280..4791317 - 1038 WP_181481908.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 50662.34 Da        Isoelectric Point: 4.9669

>T163189 WP_001314390.1 NZ_CP056260:c4786049-4784721 [Klebsiella aerogenes]
MRRTQQRLAIWMNGIRVGFWEKARGEDSLQYLPEWVVDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
AVRYQSESLEPFDLLAELGRDCVGAIQLLDVDEEPTDLFSVNYRPLSEADIATTLRNTTAASLPGRQDETDDLRLSIAGA
QEKTALLWHEEQWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLLEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMDILSHSDQAEQDKEQFFRAQIIFWLLAATDGHAKNFS
IAIEPQSHYHLTPLYDVLSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRIQRRHWINHGELTGLGRRQVESMMDDI
ISSTPEVIERVSMLLPESFPPELAECIFEGMRQQCRRLAGRE

Download         Length: 1329 bp

>T163189 NZ_CP072455:c191940-191479 [Xenorhabdus budapestensis]
ATGACTTTTTACCGATTAGTAAAATCCATTCATGCCAATGAAGCATGGACGGGGTATGGAGCCAAAAGATTTGGTGGGCG
CTGGAATCATAAGGGATACCATGCTGTCTATGTGTCCAGTTCCATCGCCCTTGCTACACTAGAACTGTATGTCCACACCT
CAAAAGAAAGCCTTCTTGAAGAATACCAGCTATTTTCTATTGAGTTAGCAGATAAAAATGTGGATTACTTGGATCACAGC
TATCTCCCTGATGACTGGAGGCGTGACCCCGCACCTGTTTCAACCATGGATATAGGTAGTGGCTGGCTAAATGCGGCAGA
AAATGTTGCCCTGATAATTCCTTCTTGTATTGTTCCTTACGAAAACAACGCCATTATCAACCCAAACCACCCTAAATTTT
CCAAATCCATTGAATCAGTTAAAGAATTAAACTTTACATTCGACCAACGCCTAATTCGTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11363.02 Da        Isoelectric Point: 10.1481

>AT163189 WP_001314389.1 NZ_CP056260:c4786359-4786054 [Klebsiella aerogenes]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMDESEQQKDSPARREKW

Download         Length: 306 bp

>AT163189 NZ_CP072455:c192383-191937 [Xenorhabdus budapestensis]
ATGAGAATCTATGTACCAAATGATACGATCAGTAAGAAAGCTCTCTGGCGCTCTGTAGGACTACCAGCAAACCGGGGAAG
TGATCTGATCGAAACCTTACAAGCCGGATTACCACTTGATGTGCTGGATAATCTTCATCGAGACTCAGAGATATCTAAAG
CCGACATTCTTCGCATTGCTGGTATCAGTGAACGTAATGTTGCACGTCGTAAAAGTTCTAGTCGCCCATTTTCACCCGAT
GAAAGCGAACGTATAGCTCGCTTGGTTCGCGTGTTTGATGCAGCCATCAATTTCTTCAATGGTGATAAAGAAGCGGCCTA
TCATTGGCTCAAGGAGCCTGTTAAAGGGCTAGGCAATATTGCACCGATTTCCCTTATCTCAACAGAAAGTGGTGCTCTTG
AAGTGATGGACCTCATTGGCCGACTGGAACATGGTGTTATTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9APU8

Antitoxin

Source ID Structure
AlphaFold DB A0A754E9C8

References