Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4128228..4128847 Replicon chromosome
Accession NZ_CP056260
Organism Klebsiella aerogenes strain RHBSTW-00898

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag HV316_RS20070 Protein ID WP_015367918.1
Coordinates 4128629..4128847 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag HV316_RS20065 Protein ID WP_015367917.1
Coordinates 4128228..4128602 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV316_RS20055 4123387..4124586 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV316_RS20060 4124609..4127755 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit -
HV316_RS20065 4128228..4128602 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
HV316_RS20070 4128629..4128847 + 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
HV316_RS20075 4128979..4129542 + 564 WP_015367919.1 maltose O-acetyltransferase -
HV316_RS20080 4129668..4130132 + 465 WP_015367920.1 YlaC family protein -
HV316_RS20085 4130107..4131561 - 1455 WP_015367921.1 PLP-dependent aminotransferase family protein -
HV316_RS20090 4131664..4132374 + 711 WP_015367922.1 GNAT family N-acetyltransferase -
HV316_RS20095 4132371..4132511 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV316_RS20100 4132514..4132774 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T163188 WP_015367918.1 NZ_CP056260:4128629-4128847 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T163188 NZ_CP072453:c4553881-4553678 [Providencia sp. R33]
ATGACCAAATCTGATTATCTGATGCGTTTAAGAAAATGCACAACAATTGAAACACTTGAGCGAGTGATTGAAAAAAATAA
GTATGAATTATCTGATGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGTCTTGCTGAACTTACAATGAATAAGC
TCTACGATAAAATCCCTGCTTCTGTTTGGAAATTTGTTAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT163188 WP_015367917.1 NZ_CP056260:4128228-4128602 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT163188 NZ_CP072453:c4554323-4553955 [Providencia sp. R33]
ATGGATGAATACTCACCCAAAAGACATGATATAGCAGAACTTAAATACTTATGTAATAGTCTGAATCGGGACGCTATTTT
AAGTTTACAACAAACAAATACACATTGGATTAATGACTTAAGTTCCGAGCAGAGCGCTGCGCTTAATGAGCTCATAGAGC
ACATCGCCGCATTTGTTTGGCGATTTAAAATCAAATATCCAAAAGAAAATCTTGTTATCTCATTAATCGAAGAGTATCTC
GATGAGACTTATGATTTATTTGGAAGCCCAATCATCACGTTAAGTGAAATTATTGATTGGGAGACAATGAATCAAAATCT
TGTTGCTGTGCTGGATGACGATCTAAAATGTCTAACCAGTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References