Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2783343..2784082 Replicon chromosome
Accession NZ_CP056260
Organism Klebsiella aerogenes strain RHBSTW-00898

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV316_RS13505 Protein ID WP_032705770.1
Coordinates 2783597..2784082 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV316_RS13500 Protein ID WP_015366659.1
Coordinates 2783343..2783609 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV316_RS13475 2778651..2779520 + 870 WP_015366654.1 5'/3'-nucleotidase SurE -
HV316_RS13480 2779774..2780253 + 480 Protein_2650 response regulator transcription factor -
HV316_RS13485 2780349..2780846 + 498 WP_015366656.1 heme-binding protein -
HV316_RS13490 2781247..2781780 + 534 WP_100280375.1 N-acetyltransferase -
HV316_RS13495 2781835..2783070 - 1236 WP_015366658.1 MFS transporter -
HV316_RS13500 2783343..2783609 + 267 WP_015366659.1 DUF1778 domain-containing protein Antitoxin
HV316_RS13505 2783597..2784082 + 486 WP_032705770.1 GNAT family N-acetyltransferase Toxin
HV316_RS13510 2784154..2785770 + 1617 WP_015366662.1 FAD-NAD(P)-binding protein -
HV316_RS13515 2785889..2786989 + 1101 WP_015366663.1 NADH:flavin oxidoreductase/NADH oxidase -
HV316_RS13520 2787046..2787204 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
HV316_RS13525 2787465..2788535 + 1071 WP_015366664.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17573.23 Da        Isoelectric Point: 8.8793

>T163187 WP_032705770.1 NZ_CP056260:2783597-2784082 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHSEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T163187 NZ_CP072453:c3572667-3572365 [Providencia sp. R33]
ATGATAACAGTATTAACAACAGATCTATTCGACAACTGGATACGGGATCTCAAGGATTTAAGGGCGAAAACCAAGATTCA
AGTGAGAATTCGGCGCCTAAAAAATGGAAATTTTGGCGATATTGAGCCGATTGGTGATGGTTTTTCAGAGCTGAGGATAC
ATGAGGGGCAAGGGTATCGCGTTTATTTAAAACAGAAAAATAACGTTATGGTCATTTTGCTCTTCGGTGGGAGTAAAGGA
ACCCAGCAAAAAGATATCATCAAAGCCAAACAGGTCTTTAGTCAAATTGAAGGTGAATTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10075.52 Da        Isoelectric Point: 4.6558

>AT163187 WP_015366659.1 NZ_CP056260:2783343-2783609 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANSALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT163187 NZ_CP072453:c3572368-3572084 [Providencia sp. R33]
ATGACCATTAAATTAAAAGAATATGATATTGCTGAGCATTTAAATAGCGAAGAAGAAATCCAATTGTATCTTAATGAGAT
CTTGGAGGAAGGTGATCCTGCTTTATTATTATCAGCCCTCGGGGATATCGCAAAAGCTCGCAATATGAGTCAATTAGCTA
AAGAGGTAGGGATGAGCCGTGAAGGTTTATATAAAGCATTGTCAGGTCAAGGTAATCCTACATTCAATACAATAATAAAA
ATAGTTAACTCTCTTGGTTTGAAGCTACAATTTAAAAGTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References