Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 1178492..1179272 Replicon chromosome
Accession NZ_CP056260
Organism Klebsiella aerogenes strain RHBSTW-00898

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag HV316_RS05715 Protein ID WP_015370123.1
Coordinates 1178492..1178821 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV316_RS05720 Protein ID WP_127175768.1
Coordinates 1178874..1179272 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV316_RS05680 1173860..1174012 - 153 WP_157844032.1 hypothetical protein -
HV316_RS05685 1174303..1174530 + 228 WP_071647620.1 DUF1272 domain-containing protein -
HV316_RS05690 1174858..1175676 + 819 WP_032706441.1 AraC family transcriptional regulator -
HV316_RS05695 1175752..1176114 + 363 WP_015370120.1 cupin domain-containing protein -
HV316_RS05700 1176314..1176850 + 537 WP_015370121.1 dihydrofolate reductase family protein -
HV316_RS05705 1177026..1177826 + 801 WP_015370122.1 nucleotidyltransferase domain-containing protein -
HV316_RS05710 1177985..1178086 - 102 Protein_1118 preprotein translocase -
HV316_RS05715 1178492..1178821 - 330 WP_015370123.1 TA system toxin CbtA family protein Toxin
HV316_RS05720 1178874..1179272 - 399 WP_127175768.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV316_RS05725 1179241..1179462 - 222 WP_015370125.1 DUF987 domain-containing protein -
HV316_RS05730 1179483..1179962 - 480 WP_015370126.1 DNA repair protein RadC -
HV316_RS05735 1179974..1180453 - 480 WP_032710462.1 antirestriction protein -
HV316_RS05740 1180470..1180724 - 255 WP_071647618.1 hypothetical protein -
HV316_RS05745 1180724..1181542 - 819 WP_015370128.1 DUF945 domain-containing protein -
HV316_RS05750 1181640..1181873 - 234 WP_181481937.1 DUF905 domain-containing protein -
HV316_RS05755 1181967..1182803 - 837 WP_015370130.1 hypothetical protein -
HV316_RS05760 1182861..1183106 - 246 WP_032710460.1 hypothetical protein -
HV316_RS05765 1183106..1183333 - 228 WP_015370132.1 hypothetical protein -
HV316_RS05770 1183406..1183813 - 408 WP_032710459.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1175752..1205427 29675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(33-131)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12493.28 Da        Isoelectric Point: 7.3984

>T163170 WP_015370123.1 NZ_CP056260:c1178821-1178492 [Klebsiella aerogenes]
MQTLSLHPTRATQPYLSPVETWQRLLTHLLSEHYGLTLNDTPFSYETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILMARRSTGLLKTTVK

Download         Length: 330 bp

>T163170 NZ_CP072422:c4759589-4759305 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTATGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14730.76 Da        Isoelectric Point: 7.0372

>AT163170 WP_127175768.1 NZ_CP056260:c1179272-1178874 [Klebsiella aerogenes]
MSSCAASRSINVNLRKAKLSNEIPAVNHDIAEPWWGLKTTVTPYFGARLVQEGNRLHYLADRASITGTFSDADLRHLDQA
FPVLLKQLELMLVSGELTSRHQHRITLYHNGLTCEADTLGSCGYVYIAIYPD

Download         Length: 399 bp

>AT163170 NZ_CP072422:c4759821-4759579 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References