163163

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4781458..4782124 Replicon chromosome
Accession NZ_CP056256
Organism Citrobacter freundii strain RHBSTW-00902

Toxin (Protein)


Gene name tad Uniprot ID A0A0J1MRN0
Locus tag HV319_RS23340 Protein ID WP_032938228.1
Coordinates 4781765..4782124 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0J1QJH0
Locus tag HV319_RS23335 Protein ID WP_032938223.1
Coordinates 4781458..4781775 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV319_RS23300 4776637..4777434 + 798 WP_003841402.1 PTS mannose/fructose/sorbose transporter subunit IIC -
HV319_RS23305 4777446..4778270 + 825 WP_048216971.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HV319_RS23310 4778338..4779570 + 1233 WP_181502024.1 L-sorbose 1-phosphate reductase -
HV319_RS23315 4779563..4780375 + 813 WP_181502025.1 shikimate 5-dehydrogenase -
HV319_RS23320 4780425..4780781 - 357 WP_032938220.1 hypothetical protein -
HV319_RS23325 4780913..4781086 + 174 WP_032938222.1 hypothetical protein -
HV319_RS23330 4781157..4781318 + 162 WP_003841416.1 phage protein -
HV319_RS23335 4781458..4781775 - 318 WP_032938223.1 helix-turn-helix domain-containing protein Antitoxin
HV319_RS23340 4781765..4782124 - 360 WP_032938228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV319_RS23345 4782338..4783027 + 690 WP_003841421.1 dipeptidase PepE -
HV319_RS23350 4783093..4784724 - 1632 WP_032938230.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13411.37 Da        Isoelectric Point: 10.3350

>T163163 WP_032938228.1 NZ_CP056256:c4782124-4781765 [Citrobacter freundii]
MTKPLYWVGHARKDLQGMPEHVRDTFGFALWLAQQGKQHSQTKSLKGFGGAGVLEVVEDHHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

>T163163 NZ_CP072422:715366-715851 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATTCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11451.29 Da        Isoelectric Point: 6.9796

>AT163163 WP_032938223.1 NZ_CP056256:c4781775-4781458 [Citrobacter freundii]
MSHEVEASSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGEEGNMSGKLKVKFG

Download         Length: 318 bp

>AT163163 NZ_CP072422:715076-715369 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MRN0

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1QJH0

References