Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3921357..3921973 Replicon chromosome
Accession NZ_CP056256
Organism Citrobacter freundii strain RHBSTW-00902

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HV319_RS19135 Protein ID WP_181501947.1
Coordinates 3921584..3921973 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag HV319_RS19130 Protein ID WP_045295158.1
Coordinates 3921357..3921587 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV319_RS19115 3916952..3917956 + 1005 WP_117273198.1 IS110-like element IS4321 family transposase -
HV319_RS19120 3918302..3920299 - 1998 WP_181501946.1 choline BCCT transporter BetT -
HV319_RS19125 3920621..3920887 - 267 Protein_3757 IS5/IS1182 family transposase -
HV319_RS19130 3921357..3921587 + 231 WP_045295158.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HV319_RS19135 3921584..3921973 + 390 WP_181501947.1 type II toxin-antitoxin system VapC family toxin Toxin
HV319_RS19140 3922011..3923098 + 1088 WP_088569307.1 IS3 family transposase -
HV319_RS19145 3923895..3924854 + 960 WP_181502595.1 sensor domain-containing diguanylate cyclase -
HV319_RS19150 3925263..3925967 + 705 WP_181501948.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3914353..3947988 33635
- inside IScluster/Tn - - 3913838..3928234 14396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-120)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13411.30 Da        Isoelectric Point: 6.4469

>T163161 WP_181501947.1 NZ_CP056256:3921584-3921973 [Citrobacter freundii]
VNRTYMLDTRFCAFILREQPEAVLTRLEQAVLRGHRIVISAVTWAELSQAARASGPATQALADAFCASLDAVLAWDRAAV
EATTEVKASLAAAGTPIGPNDTAIAGHAIAAGAVLVTRNGNPPEKAVCS

Download         Length: 390 bp

>T163161 NZ_CP072422:331828-332196 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8641.84 Da        Isoelectric Point: 6.3000

>AT163161 WP_045295158.1 NZ_CP056256:3921357-3921587 [Citrobacter freundii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGNCIILRPVRPSWSSFAMMGRADPEFMAERGDVVSDKGRSEQ

Download         Length: 231 bp

>AT163161 NZ_CP072422:331610-331831 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References