Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 934341..935113 | Replicon | chromosome |
Accession | NZ_CP056256 | ||
Organism | Citrobacter freundii strain RHBSTW-00902 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A2I8S4E2 |
Locus tag | HV319_RS04565 | Protein ID | WP_065805889.1 |
Coordinates | 934724..935113 (+) | Length | 130 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | - |
Locus tag | HV319_RS04560 | Protein ID | WP_171820947.1 |
Coordinates | 934341..934667 (+) | Length | 109 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV319_RS04530 | 930786..931418 | - | 633 | WP_072032909.1 | inovirus Gp2 family protein | - |
HV319_RS04535 | 931956..932780 | + | 825 | WP_065805884.1 | DUF945 domain-containing protein | - |
HV319_RS04540 | 932777..933034 | + | 258 | WP_044349282.1 | DUF905 domain-containing protein | - |
HV319_RS04545 | 933114..933557 | + | 444 | WP_065805885.1 | antirestriction protein | - |
HV319_RS04550 | 933569..934048 | + | 480 | WP_128301357.1 | DNA repair protein RadC | - |
HV319_RS04555 | 934062..934283 | + | 222 | WP_053895773.1 | DUF987 domain-containing protein | - |
HV319_RS04560 | 934341..934667 | + | 327 | WP_171820947.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
HV319_RS04565 | 934724..935113 | + | 390 | WP_065805889.1 | TA system toxin CbtA family protein | Toxin |
HV319_RS04570 | 935200..936039 | + | 840 | WP_128301359.1 | DUF4942 domain-containing protein | - |
HV319_RS04575 | 936777..936998 | + | 222 | WP_003846405.1 | hypothetical protein | - |
HV319_RS04580 | 937035..937667 | + | 633 | WP_003838326.1 | hypothetical protein | - |
HV319_RS04585 | 937751..938020 | - | 270 | WP_064375540.1 | hypothetical protein | - |
HV319_RS04590 | 938096..938404 | - | 309 | WP_170864030.1 | hypothetical protein | - |
HV319_RS04595 | 938386..938583 | - | 198 | WP_044700790.1 | hypothetical protein | - |
HV319_RS04600 | 938677..939255 | - | 579 | WP_061549908.1 | tyrosine-type recombinase/integrase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 905515..947183 | 41668 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 130 a.a. Molecular weight: 14321.40 Da Isoelectric Point: 9.9883
>T163151 WP_065805889.1 NZ_CP056256:934724-935113 [Citrobacter freundii]
MQTKSSPLMRAASSRPSPVSVWQTLLTSLLAQHYGLTLSDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGF
SILTQSPFITPIDILRARKATGLMNRDTYKEVTAITRGQHPQVSAPGKR
MQTKSSPLMRAASSRPSPVSVWQTLLTSLLAQHYGLTLSDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGF
SILTQSPFITPIDILRARKATGLMNRDTYKEVTAITRGQHPQVSAPGKR
Download Length: 390 bp
>T163151 NZ_CP072408:c5278110-5277727 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12113.85 Da Isoelectric Point: 6.9554
>AT163151 WP_171820947.1 NZ_CP056256:934341-934667 [Citrobacter freundii]
ISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFNGQFCDADLRHLDQAFPVLMKQLELMLTSGELNPRHQHGIILYA
KGLTCEADTLGSHGYVYIAIYPTPVATA
ISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFNGQFCDADLRHLDQAFPVLMKQLELMLTSGELNPRHQHGIILYA
KGLTCEADTLGSHGYVYIAIYPTPVATA
Download Length: 327 bp
>AT163151 NZ_CP072408:c5278352-5278110 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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