Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4574419..4574995 Replicon chromosome
Accession NZ_CP056251
Organism Citrobacter sp. RHBSTW-00903

Toxin (Protein)


Gene name shpA Uniprot ID A0A2I8S420
Locus tag HV320_RS22670 Protein ID WP_049269953.1
Coordinates 4574708..4574995 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A2I8S1U6
Locus tag HV320_RS22665 Protein ID WP_016155614.1
Coordinates 4574419..4574721 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV320_RS22640 4569689..4569883 + 195 WP_003830038.1 YbdD/YjiX family protein -
HV320_RS22645 4569896..4570852 + 957 WP_049040419.1 GTPase -
HV320_RS22650 4571039..4572613 + 1575 Protein_4449 AAA family ATPase -
HV320_RS22660 4573833..4574111 + 279 Protein_4451 ATP-binding domain-containing protein -
HV320_RS22665 4574419..4574721 - 303 WP_016155614.1 BrnA antitoxin family protein Antitoxin
HV320_RS22670 4574708..4574995 - 288 WP_049269953.1 BrnT family toxin Toxin
HV320_RS22675 4575227..4576393 + 1167 WP_019078303.1 restriction endonuclease -
HV320_RS22680 4576456..4576596 - 141 WP_165500049.1 hypothetical protein -
HV320_RS22685 4576559..4576857 + 299 Protein_4456 type I addiction module toxin, SymE family -
HV320_RS22690 4576988..4577479 - 492 WP_016151575.1 type VI secretion system tube protein Hcp -
HV320_RS22695 4577480..4577986 - 507 WP_047414535.1 hypothetical protein -
HV320_RS22700 4577986..4578348 - 363 WP_046275905.1 DUF2778 domain-containing protein -
HV320_RS22705 4578623..4579687 - 1065 WP_049041982.1 DUF2955 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(42-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11433.87 Da        Isoelectric Point: 8.6051

>T163143 WP_049269953.1 NZ_CP056251:c4574995-4574708 [Citrobacter sp. RHBSTW-00903]
MPMEFEWDANKAQSNHRKHGVRFEDAILVFDDPQHLSRQERYENGEYRWQTIGLVHGIVVILVAHSVRFESRFEVIRIIS
ARKADRKERNRYEHS

Download         Length: 288 bp

>T163143 NZ_CP072408:335828-336196 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11466.12 Da        Isoelectric Point: 10.1293

>AT163143 WP_016155614.1 NZ_CP056251:c4574721-4574419 [Citrobacter sp. RHBSTW-00903]
MSIVKHKRGSVSALSAQHEAELKALANKPDDDIDYSDIPVTEDKQWSEAIRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT163143 NZ_CP072408:335610-335831 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S420

Antitoxin

Source ID Structure
AlphaFold DB A0A2I8S1U6

References