Detailed information of TA system TA163130

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1170369..1171036
• Replicon: chromosome
• Accession: NZ_CP056251
• Organism: Citrobacter sp. RHBSTW-00903

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: HV320_RS05660
• Protein ID: WP_057064441.1
• Coordinates: 1170369..1170698 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV320_RS05665
• Protein ID: WP_007870247.1
• Coordinates: 1170719..1171036 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV320_RS05635	1166080..1166436	-	357	WP_016157245.1	hypothetical protein	-
HV320_RS05640	1167083..1168063	-	981	WP_000019445.1	IS5-like element ISKpn26 family transposase	-
HV320_RS05645	1168108..1168782	+	675	WP_181533313.1	YafY family transcriptional regulator	-
HV320_RS05650	1168853..1169599	+	747	WP_016157243.1	SDR family oxidoreductase	-
HV320_RS05655	1169790..1169972	-	183	WP_016157242.1	hypothetical protein	-
HV320_RS05660	1170369..1170698	-	330	WP_057064441.1	TA system toxin CbtA family protein	Toxin
HV320_RS05665	1170719..1171036	-	318	WP_007870247.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV320_RS05670	1171054..1171275	-	222	WP_001548165.1	DUF987 domain-containing protein	-
HV320_RS05675	1171284..1171760	-	477	WP_057064440.1	RadC family protein	-
HV320_RS05680	1171776..1172255	-	480	WP_081014411.1	antirestriction protein	-
HV320_RS05685	1173109..1175304	-	2196	WP_106672555.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1168192..1193541	25349
	-	flank	IS/Tn	-	-	1167083..1168063	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12424.59 Da
• Isoelectric Point: 10.1006

>T163130 WP_057064441.1 NZ_CP056251:c1170698-1170369 [Citrobacter sp. RHBSTW-00903]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFWDQTVIKEHIDAGITLADAVNFLVDKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSTGLLKAKVK

Nucleotide

• Length: 330 bp

>T163130 NZ_CP072398:1915438-1915620 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11839.44 Da
• Isoelectric Point: 6.9459

>AT163130 WP_007870247.1 NZ_CP056251:c1171036-1170719 [Citrobacter sp. RHBSTW-00903]
MNNTTWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT163130 NZ_CP072398:1915713-1916117 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG