163128

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 154734..155260 Replicon plasmid pRHBSTW-00915_2
Accession NZ_CP056246
Organism Citrobacter freundii strain RHBSTW-00915

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HV325_RS25005 Protein ID WP_000323025.1
Coordinates 154973..155260 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HV325_RS25000 Protein ID WP_000534858.1
Coordinates 154734..154973 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV325_RS24985 151062..152300 + 1239 WP_003030308.1 IS110 family transposase -
HV325_RS24990 152776..153348 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
HV325_RS24995 153548..154471 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
HV325_RS25000 154734..154973 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HV325_RS25005 154973..155260 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HV325_RS25010 155358..156017 + 660 WP_008786574.1 hypothetical protein -
HV325_RS25015 156066..156311 + 246 WP_007372330.1 hypothetical protein -
HV325_RS25020 156515..159892 + 3378 WP_102016262.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..178786 178786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T163128 WP_000323025.1 NZ_CP056246:154973-155260 [Citrobacter freundii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T163128 NZ_CP072396:c4545773-4545621 [Xanthomonas citri pv. fuscans]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT163128 WP_000534858.1 NZ_CP056246:154734-154973 [Citrobacter freundii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT163128 NZ_CP072396:c4545546-4545412 [Xanthomonas citri pv. fuscans]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References