Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4624517..4625183 Replicon chromosome
Accession NZ_CP056245
Organism Citrobacter freundii strain RHBSTW-00915

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag HV325_RS22530 Protein ID WP_049016185.1
Coordinates 4624824..4625183 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag HV325_RS22525 Protein ID WP_049016184.1
Coordinates 4624517..4624834 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV325_RS22495 4620185..4621009 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HV325_RS22500 4621077..4622300 + 1224 WP_048241807.1 L-sorbose 1-phosphate reductase -
HV325_RS22505 4622302..4623114 + 813 WP_049016181.1 shikimate 5-dehydrogenase -
HV325_RS22510 4623166..4623522 - 357 WP_049016182.1 hypothetical protein -
HV325_RS22515 4623664..4623825 + 162 WP_003841416.1 phage protein -
HV325_RS22520 4624229..4624507 + 279 WP_049016183.1 putative addiction module antidote protein -
HV325_RS22525 4624517..4624834 - 318 WP_049016184.1 helix-turn-helix domain-containing protein Antitoxin
HV325_RS22530 4624824..4625183 - 360 WP_049016185.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV325_RS22535 4625397..4626086 + 690 WP_003841421.1 dipeptidase PepE -
HV325_RS22540 4626152..4627783 - 1632 WP_049016186.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13442.55 Da        Isoelectric Point: 10.3349

>T163125 WP_049016185.1 NZ_CP056245:c4625183-4624824 [Citrobacter freundii]
MTKPLYWVGQARKDLLAMPEHVRDTFGFALWLAQQGKQQSQTKPLKGFGGAGVLEVVEDHHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAVQRHAQESGYVI

Download         Length: 360 bp

>T163125 NZ_CP072395:c28670-28254 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11474.35 Da        Isoelectric Point: 8.9375

>AT163125 WP_049016184.1 NZ_CP056245:c4624834-4624517 [Citrobacter freundii]
MSYEVEASSGNVYVDLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNTSGKLKVKFG

Download         Length: 318 bp

>AT163125 NZ_CP072395:c28921-28667 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References