Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3666724..3667344 | Replicon | chromosome |
Accession | NZ_CP056245 | ||
Organism | Citrobacter freundii strain RHBSTW-00915 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | HV325_RS18060 | Protein ID | WP_002892050.1 |
Coordinates | 3667126..3667344 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | R8WZW8 |
Locus tag | HV325_RS18055 | Protein ID | WP_003021733.1 |
Coordinates | 3666724..3667098 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV325_RS18045 | 3661870..3663063 | + | 1194 | WP_049015706.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
HV325_RS18050 | 3663086..3666235 | + | 3150 | WP_003021736.1 | multidrug efflux RND transporter permease subunit | - |
HV325_RS18055 | 3666724..3667098 | + | 375 | WP_003021733.1 | Hha toxicity modulator TomB | Antitoxin |
HV325_RS18060 | 3667126..3667344 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
HV325_RS18065 | 3667526..3668077 | + | 552 | WP_049015707.1 | maltose O-acetyltransferase | - |
HV325_RS18070 | 3668194..3668664 | + | 471 | WP_003021724.1 | YlaC family protein | - |
HV325_RS18075 | 3668743..3668883 | - | 141 | WP_005125190.1 | type B 50S ribosomal protein L36 | - |
HV325_RS18080 | 3668885..3669145 | - | 261 | WP_003835926.1 | type B 50S ribosomal protein L31 | - |
HV325_RS18085 | 3669334..3670887 | + | 1554 | WP_003835927.1 | EAL domain-containing protein | - |
HV325_RS18090 | 3670939..3671292 | - | 354 | WP_003831033.1 | DUF1428 family protein | - |
HV325_RS18095 | 3671357..3671986 | - | 630 | WP_049015708.1 | membrane protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T163123 WP_002892050.1 NZ_CP056245:3667126-3667344 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T163123 NZ_CP072393:c4994454-4994341 [Xanthomonas phaseoli pv. phaseoli]
TTGAAGGGCGAGCGGCGCGGCCAGTACCGCATCCGGATCAACGATCGATGGCGCATCTGCGTCCGATGGATGGAAGGCGA
TGTGGTCCAGGTCGAAATCATCGATTACCACTGA
TTGAAGGGCGAGCGGCGCGGCCAGTACCGCATCCGGATCAACGATCGATGGCGCATCTGCGTCCGATGGATGGAAGGCGA
TGTGGTCCAGGTCGAAATCATCGATTACCACTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14427.23 Da Isoelectric Point: 5.5653
>AT163123 WP_003021733.1 NZ_CP056245:3666724-3667098 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT163123 NZ_CP072393:c4994323-4994033 [Xanthomonas phaseoli pv. phaseoli]
ATGACGGTCCTGCCCAATATCCACCCTGGCGCAATTCTGCTTGAGGAGTTTCTCCAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGAACCTTCGAGCGCTTCTGGCTTGGCCTGCAGGCCGACGACGAGCTGGAGCAGGCG
CATCGCGCGCTGGGCGACTTGCCGGCGCGGATCAAGCGGCTGGCGGCATGA
ATGACGGTCCTGCCCAATATCCACCCTGGCGCAATTCTGCTTGAGGAGTTTCTCCAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGAACCTTCGAGCGCTTCTGGCTTGGCCTGCAGGCCGACGACGAGCTGGAGCAGGCG
CATCGCGCGCTGGGCGACTTGCCGGCGCGGATCAAGCGGCTGGCGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | R8WZW8 |