Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1439969..1440495 Replicon chromosome
Accession NZ_CP056245
Organism Citrobacter freundii strain RHBSTW-00915

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HV325_RS06990 Protein ID WP_000323025.1
Coordinates 1440208..1440495 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HV325_RS06985 Protein ID WP_000534858.1
Coordinates 1439969..1440208 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV325_RS06970 1436297..1437535 + 1239 WP_003030308.1 IS110 family transposase -
HV325_RS06975 1438011..1438583 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
HV325_RS06980 1438783..1439706 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
HV325_RS06985 1439969..1440208 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HV325_RS06990 1440208..1440495 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HV325_RS06995 1440840..1443110 + 2271 WP_049014902.1 sensor domain-containing phosphodiesterase -
HV325_RS07000 1443090..1444631 - 1542 WP_003037914.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T163111 WP_000323025.1 NZ_CP056245:1440208-1440495 [Citrobacter freundii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T163111 NZ_CP072385:2924340-2924600 [Arachnia propionica]
ATGCGGATCTGCTGGGCCGACGAAGCGTGGGAGGACTACCTCTGGTGGCAAACCCAGGACCGCCGGACCCTCAAGAGAAT
CAACTCCCTGATCCGGGACATCGCTCGCAACGGAAACGAGGAACTGGGCAAACCGGAGGCGCTGCGATACCAACTCTCCG
GCTACTGGTCCCGGCGTATCACTGAGGAGCATCGGCTGGTCTACCGAATCACCGACACCGAGGTCCAGATTGCCGCATGC
CGGTACCACTATGGCCGCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT163111 WP_000534858.1 NZ_CP056245:1439969-1440208 [Citrobacter freundii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT163111 NZ_CP072385:2924090-2924338 [Arachnia propionica]
ATGTCGTACACCGAGTCCCGAGCCAACTACGCGGCGGTCCTCGACGAGGTCGTGAACAATCGCGAGGAGATCGTCATCAC
CCGGGCAGGACACGAACCCGTCGTGATCGTCTCCCTGGAGGAGTACCAGTCCCTTCGCGAGACCGCCTACCTGTTGCGTT
CGCCCGCCAACGCCCAGCGGCTGGCCAGCGCCATGGAACAGCTCGACAGGAACGACGGCATCCCGCACGACCTCCTCGAC
GACCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References