163111

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1439969..1440495 Replicon chromosome
Accession NZ_CP056245
Organism Citrobacter freundii strain RHBSTW-00915

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HV325_RS06990 Protein ID WP_000323025.1
Coordinates 1440208..1440495 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HV325_RS06985 Protein ID WP_000534858.1
Coordinates 1439969..1440208 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV325_RS06970 1436297..1437535 + 1239 WP_003030308.1 IS110 family transposase -
HV325_RS06975 1438011..1438583 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
HV325_RS06980 1438783..1439706 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
HV325_RS06985 1439969..1440208 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HV325_RS06990 1440208..1440495 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HV325_RS06995 1440840..1443110 + 2271 WP_049014902.1 sensor domain-containing phosphodiesterase -
HV325_RS07000 1443090..1444631 - 1542 WP_003037914.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T163111 WP_000323025.1 NZ_CP056245:1440208-1440495 [Citrobacter freundii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T163111 NZ_CP072385:2924340-2924600 [Arachnia propionica]
ATGCGGATCTGCTGGGCCGACGAAGCGTGGGAGGACTACCTCTGGTGGCAAACCCAGGACCGCCGGACCCTCAAGAGAAT
CAACTCCCTGATCCGGGACATCGCTCGCAACGGAAACGAGGAACTGGGCAAACCGGAGGCGCTGCGATACCAACTCTCCG
GCTACTGGTCCCGGCGTATCACTGAGGAGCATCGGCTGGTCTACCGAATCACCGACACCGAGGTCCAGATTGCCGCATGC
CGGTACCACTATGGCCGCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT163111 WP_000534858.1 NZ_CP056245:1439969-1440208 [Citrobacter freundii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT163111 NZ_CP072385:2924090-2924338 [Arachnia propionica]
ATGTCGTACACCGAGTCCCGAGCCAACTACGCGGCGGTCCTCGACGAGGTCGTGAACAATCGCGAGGAGATCGTCATCAC
CCGGGCAGGACACGAACCCGTCGTGATCGTCTCCCTGGAGGAGTACCAGTCCCTTCGCGAGACCGCCTACCTGTTGCGTT
CGCCCGCCAACGCCCAGCGGCTGGCCAGCGCCATGGAACAGCTCGACAGGAACGACGGCATCCCGCACGACCTCCTCGAC
GACCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References