Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 246808..247439 | Replicon | chromosome |
Accession | NZ_CP056245 | ||
Organism | Citrobacter freundii strain RHBSTW-00915 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A0J1MPQ6 |
Locus tag | HV325_RS01155 | Protein ID | WP_003837806.1 |
Coordinates | 246808..247083 (+) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A0J1MMS0 |
Locus tag | HV325_RS01160 | Protein ID | WP_003837808.1 |
Coordinates | 247080..247439 (+) | Length | 120 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV325_RS01145 | 242859..245606 | + | 2748 | WP_049025788.1 | ribosome-associated ATPase/putative transporter RbbA | - |
HV325_RS01150 | 245606..246730 | + | 1125 | WP_049014297.1 | ABC transporter permease | - |
HV325_RS01155 | 246808..247083 | + | 276 | WP_003837806.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
HV325_RS01160 | 247080..247439 | + | 360 | WP_003837808.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
HV325_RS01165 | 247552..247953 | - | 402 | WP_032937232.1 | nickel-responsive transcriptional regulator NikR | - |
HV325_RS01170 | 248003..248581 | - | 579 | WP_003023390.1 | 4'-phosphopantetheinyl transferase AcpT | - |
HV325_RS01175 | 248644..249693 | - | 1050 | WP_003023393.1 | AI-2E family transporter | - |
HV325_RS01180 | 249827..251044 | + | 1218 | WP_016151126.1 | MFS transporter | - |
HV325_RS01185 | 251048..251605 | - | 558 | WP_003837816.1 | DcrB family lipoprotein | - |
HV325_RS01190 | 251678..252343 | - | 666 | WP_003837818.1 | 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10210.88 Da Isoelectric Point: 10.7228
>T163107 WP_003837806.1 NZ_CP056245:246808-247083 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP
Download Length: 276 bp
>T163107 NZ_CP072385:661992-662354 [Arachnia propionica]
GTGATCCTCGTCGACACCTCCGTCTGGATCGACCACTTCCGTCGCAGCGACCTGCGTCTGGTGCGCCTGCTGCGCGGAGA
CGAGGCAGGCTGCCACGCCATGGTCATCGGGGAGCTGTCGCTGAGTTCCATGCCCGCCCGCACGGTGCGGATGTCATACC
TGTCGAACCTGTACCGGTTCCCCAGCCTCCACGACGACGAACTGCTGCACCTCGTCGAGACCAGACGGTTGTGGGGTCGC
GGCCTCAGCCTGGTTGACGTCAACCTCATCGGCTCCGTCCTGGTGGTCCCGGGGGCCTGCCTGTGGACCCGCGACAAACG
TCTCCGGGCGGTCGCCAAGGAGCTGGAGATCGCCTTCGAGTGA
GTGATCCTCGTCGACACCTCCGTCTGGATCGACCACTTCCGTCGCAGCGACCTGCGTCTGGTGCGCCTGCTGCGCGGAGA
CGAGGCAGGCTGCCACGCCATGGTCATCGGGGAGCTGTCGCTGAGTTCCATGCCCGCCCGCACGGTGCGGATGTCATACC
TGTCGAACCTGTACCGGTTCCCCAGCCTCCACGACGACGAACTGCTGCACCTCGTCGAGACCAGACGGTTGTGGGGTCGC
GGCCTCAGCCTGGTTGACGTCAACCTCATCGGCTCCGTCCTGGTGGTCCCGGGGGCCTGCCTGTGGACCCGCGACAAACG
TCTCCGGGCGGTCGCCAAGGAGCTGGAGATCGCCTTCGAGTGA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13198.98 Da Isoelectric Point: 4.5462
>AT163107 WP_003837808.1 NZ_CP056245:247080-247439 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA
Download Length: 360 bp
>AT163107 NZ_CP072385:661789-661995 [Arachnia propionica]
ATGAGAACCACCGTTACCCTGGACGACGACTTGGTGGCACGCGCCCAGGAACTGACCGGCGTCAAGGAACGTTCCGTCCT
GCTCCGTGAGGGCCTCGAGACGCTGATTCGCGTCGAGAGCGCCCGCCGCCTGGCCGCGCTCGGCGGCACCGAACCGGAGG
CGCAGATATCGTCGCGGACCCGGGACCTCGGGGACCTCGCGAAGTGA
ATGAGAACCACCGTTACCCTGGACGACGACTTGGTGGCACGCGCCCAGGAACTGACCGGCGTCAAGGAACGTTCCGTCCT
GCTCCGTGAGGGCCTCGAGACGCTGATTCGCGTCGAGAGCGCCCGCCGCCTGGCCGCGCTCGGCGGCACCGAACCGGAGG
CGCAGATATCGTCGCGGACCCGGGACCTCGGGGACCTCGCGAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0J1MPQ6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0J1MMS0 |