Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 246808..247439 Replicon chromosome
Accession NZ_CP056245
Organism Citrobacter freundii strain RHBSTW-00915

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag HV325_RS01155 Protein ID WP_003837806.1
Coordinates 246808..247083 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag HV325_RS01160 Protein ID WP_003837808.1
Coordinates 247080..247439 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV325_RS01145 242859..245606 + 2748 WP_049025788.1 ribosome-associated ATPase/putative transporter RbbA -
HV325_RS01150 245606..246730 + 1125 WP_049014297.1 ABC transporter permease -
HV325_RS01155 246808..247083 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
HV325_RS01160 247080..247439 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV325_RS01165 247552..247953 - 402 WP_032937232.1 nickel-responsive transcriptional regulator NikR -
HV325_RS01170 248003..248581 - 579 WP_003023390.1 4'-phosphopantetheinyl transferase AcpT -
HV325_RS01175 248644..249693 - 1050 WP_003023393.1 AI-2E family transporter -
HV325_RS01180 249827..251044 + 1218 WP_016151126.1 MFS transporter -
HV325_RS01185 251048..251605 - 558 WP_003837816.1 DcrB family lipoprotein -
HV325_RS01190 251678..252343 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T163107 WP_003837806.1 NZ_CP056245:246808-247083 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

>T163107 NZ_CP072385:661992-662354 [Arachnia propionica]
GTGATCCTCGTCGACACCTCCGTCTGGATCGACCACTTCCGTCGCAGCGACCTGCGTCTGGTGCGCCTGCTGCGCGGAGA
CGAGGCAGGCTGCCACGCCATGGTCATCGGGGAGCTGTCGCTGAGTTCCATGCCCGCCCGCACGGTGCGGATGTCATACC
TGTCGAACCTGTACCGGTTCCCCAGCCTCCACGACGACGAACTGCTGCACCTCGTCGAGACCAGACGGTTGTGGGGTCGC
GGCCTCAGCCTGGTTGACGTCAACCTCATCGGCTCCGTCCTGGTGGTCCCGGGGGCCTGCCTGTGGACCCGCGACAAACG
TCTCCGGGCGGTCGCCAAGGAGCTGGAGATCGCCTTCGAGTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT163107 WP_003837808.1 NZ_CP056245:247080-247439 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp

>AT163107 NZ_CP072385:661789-661995 [Arachnia propionica]
ATGAGAACCACCGTTACCCTGGACGACGACTTGGTGGCACGCGCCCAGGAACTGACCGGCGTCAAGGAACGTTCCGTCCT
GCTCCGTGAGGGCCTCGAGACGCTGATTCGCGTCGAGAGCGCCCGCCGCCTGGCCGCGCTCGGCGGCACCGAACCGGAGG
CGCAGATATCGTCGCGGACCCGGGACCTCGGGGACCTCGCGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References