Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2403308..2404077 Replicon chromosome
Accession NZ_CP056244
Organism Citrobacter freundii strain RHBSTW-00923

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV327_RS11245 Protein ID WP_181518299.1
Coordinates 2403595..2404077 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV327_RS11240 Protein ID WP_168246960.1
Coordinates 2403308..2403604 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV327_RS11225 2398808..2399995 + 1188 WP_146716827.1 outer membrane protein transport protein -
HV327_RS11230 2400275..2400904 + 630 WP_181518298.1 winged helix-turn-helix transcriptional regulator -
HV327_RS11235 2401213..2403195 + 1983 WP_117342783.1 MBL fold metallo-hydrolase -
HV327_RS11240 2403308..2403604 + 297 WP_168246960.1 DUF1778 domain-containing protein Antitoxin
HV327_RS11245 2403595..2404077 + 483 WP_181518299.1 GNAT family N-acetyltransferase Toxin
HV327_RS11250 2404281..2405072 - 792 WP_181518300.1 SDR family oxidoreductase -
HV327_RS11255 2405221..2406114 + 894 WP_137363300.1 LysR family transcriptional regulator -
HV327_RS11260 2406149..2407138 - 990 WP_181518301.1 aldo/keto reductase -
HV327_RS11265 2407165..2407455 - 291 Protein_2207 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-146)

Antitoxin

Vibrio phage ICP1, Orf50

(17-91)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17702.31 Da        Isoelectric Point: 7.2887

>T163103 WP_181518299.1 NZ_CP056244:2403595-2404077 [Citrobacter freundii]
MEINVTAPALLTEGHELQPFDCGNEVLNDWLRRRAIKNQYLNASRTFVICLESTQCVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDASTQGHSYGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

>T163103 NZ_CP072384:2976716-2977114 [Arachnia rubra]
ATGATCCGCTATCTCCTGGACGCCAACGTCTTGATAGCCCTCACCGCAGCCGAACACGAACACCATGAGGCCGCAGGTGA
GTGGCTCGCAGAAACCACCCAGTTCGCGACCTGCCCCACCACAGAAAGTGCTCTACTGCGTTTCCTCCTTGGTTTGGGCG
AACCAGCCACCATGGCTCTGGAACGCATCCGGCTCATCAGGGCACTCCCTGCTGCCGAGTTCTGGCCCAGCGACCTGTCA
TACGCCGATATCGACGCCACTGGCCTGATCGGTCACCGCCAAGCCACAGATCTCTATCTCGTCTCCCTGGCTGCCGCGCA
CGGCGGACTCCTCGCCACCTTCGACAAGGCCCTTCATGCCTCCCGACCAGACCTGACCTTTCTGATCCCTCGCCCATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11515.11 Da        Isoelectric Point: 5.8990

>AT163103 WP_168246960.1 NZ_CP056244:2403308-2403604 [Citrobacter freundii]
MEKLMQTSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAP
VQNVEGRQRLMDVKPEWK

Download         Length: 297 bp

>AT163103 NZ_CP072384:2976486-2976719 [Arachnia rubra]
ATGCGCACCACGGTCGATCTACCCCCTGCAGTCCGAGAAAGAGCACAGGAGATAGCTCAACTACAGGGCCGCTCACTATC
AGCCGTCGTAGCAGAGCTGGCGACCCGGGGGCTTGCCCAGCTCGATGACCACCCAGCCATCATCGAAACCGATCCCCGCA
CCGGCTTCCCCGTTCTACGCATTGGCAGATCCATCACAAACGAACAGGTTGCAGACCTCATCGAGGAGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References