Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 782860..783514 Replicon chromosome
Accession NZ_CP056244
Organism Citrobacter freundii strain RHBSTW-00923

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HV327_RS03845 Protein ID WP_096755799.1
Coordinates 783107..783514 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HV327_RS03840 Protein ID WP_096755798.1
Coordinates 782860..783126 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV327_RS03815 778074..779507 - 1434 WP_181517849.1 6-phospho-beta-glucosidase BglA -
HV327_RS03820 779628..780356 - 729 WP_115259901.1 MurR/RpiR family transcriptional regulator -
HV327_RS03825 780409..780720 + 312 WP_096755795.1 N(4)-acetylcytidine aminohydrolase -
HV327_RS03830 780884..781543 + 660 WP_181517850.1 hemolysin III family protein -
HV327_RS03835 781623..782603 - 981 WP_181517851.1 tRNA-modifying protein YgfZ -
HV327_RS03840 782860..783126 + 267 WP_096755798.1 FAD assembly factor SdhE Antitoxin
HV327_RS03845 783107..783514 + 408 WP_096755799.1 protein YgfX Toxin
HV327_RS03850 783560..784081 - 522 WP_096755800.1 flavodoxin FldB -
HV327_RS03855 784194..785090 + 897 WP_096755801.1 site-specific tyrosine recombinase XerD -
HV327_RS03860 785114..785827 + 714 WP_096755802.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV327_RS03865 785833..787566 + 1734 WP_115257543.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15935.93 Da        Isoelectric Point: 11.2851

>T163094 WP_096755799.1 NZ_CP056244:783107-783514 [Citrobacter freundii]
VVQWQSDLRVSWRAQWISLLIHGLVAVLILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLRSSTGKRQHLWLAADSMDDAEWRDLRRLILQPSMQK

Download         Length: 408 bp

>T163094 NZ_CP072377:1536781-1537065 [Leptotrichia sp. oral taxon 218]
ATGAAGATGAATAAGTATAATTTAAAATATACAAATAGGTTTTCTAAAGATTTAAAATTAATAAAAAAGCGTGGGTATAA
TCTAAAATTACTTGAAAAAGTAGTTGAAATATTGATTAATCGTGAAAAATTGTCTGTAAAAAATAAAGATTATGCTTTAA
AAAATAAATATTTAGGGTATCGTGAGTGCTGTATAACATCTGATTGGTTGTTAGTATATAAAATAAAAGGTGAGGAATTA
ATATTTCTAACAACGAAAACAAAAACTCCGAGCAGTTTATTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10570.10 Da        Isoelectric Point: 5.6311

>AT163094 WP_096755798.1 NZ_CP056244:782860-783126 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163094 NZ_CP072377:1536516-1536794 [Leptotrichia sp. oral taxon 218]
ATGCCAACGGTTAGTACAAGTATAAAAATAGATGCCAAAACAAAGAAAGAAGCACAAGAATTATTTAAAGATATGGGAAT
GAGTTTAACTGCAGCAATAAATATATTCTTGAAACAGGCAGTAAGAGAGCAGAGAATACCTTTTTATGTTGGAGAGCCAA
AATATAAGGAAGAAGTTTATCAAGCTATGAAAGATGTAGAACAAGGTAAGAATTTGAGCAAGTCTTATCATAGTGCTAGA
GAAATGATAGAGGATATTTTGAAAGATGAAGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References