163087

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4776789..4777455 Replicon chromosome
Accession NZ_CP056238
Organism Citrobacter freundii strain RHBSTW-00935

Toxin (Protein)


Gene name tad Uniprot ID A0A0J1MRN0
Locus tag HV330_RS23320 Protein ID WP_032938228.1
Coordinates 4777096..4777455 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0J1QJH0
Locus tag HV330_RS23315 Protein ID WP_032938223.1
Coordinates 4776789..4777106 (-) Length 106 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV330_RS23280 4771968..4772765 + 798 WP_003841402.1 PTS mannose/fructose/sorbose transporter subunit IIC -
HV330_RS23285 4772777..4773601 + 825 WP_048216971.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HV330_RS23290 4773669..4774901 + 1233 WP_181502024.1 L-sorbose 1-phosphate reductase -
HV330_RS23295 4774894..4775706 + 813 WP_181502025.1 shikimate 5-dehydrogenase -
HV330_RS23300 4775756..4776112 - 357 WP_032938220.1 hypothetical protein -
HV330_RS23305 4776244..4776417 + 174 WP_032938222.1 hypothetical protein -
HV330_RS23310 4776488..4776649 + 162 WP_003841416.1 phage protein -
HV330_RS23315 4776789..4777106 - 318 WP_032938223.1 helix-turn-helix domain-containing protein Antitoxin
HV330_RS23320 4777096..4777455 - 360 WP_032938228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV330_RS23325 4777669..4778358 + 690 WP_003841421.1 dipeptidase PepE -
HV330_RS23330 4778424..4780055 - 1632 WP_032938230.1 Na/Pi cotransporter family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-106)

Antitoxin

(12-90)


Sequences


Toxin        


Download         Length: 120 a.a.        Molecular weight: 13411.37 Da        Isoelectric Point: 10.3350

>T163087 WP_032938228.1 NZ_CP056238:c4777455-4777096 [Citrobacter freundii]
MTKPLYWVGHARKDLQGMPEHVRDTFGFALWLAQQGKQHSQTKSLKGFGGAGVLEVVEDHHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

>T163087 NZ_CP072326:2632249-2633559 [Aeromonas caviae]
ATGGCCAGCCTGACGGTCTACATGAACGGATACCGGGTAGGTACCTTTACCAAGGCGACCAATGGTGCTCACCAATTTCA
GTACGATGAATCGTGGGTGAAGTTGCCAGGCAGCCGCCCCATCTCGCTCTCCATGCCATTACGCCAGCAGCGCTACCAGG
GCGATGAGGCCTATAACTTCTTCGATAATCTGCTGCCAGATAACCCGGAAGTAAGAAACCGGGTGGTGGCGCGCTATCAA
GCCGATTCCACCCAACCCTTTGATCTGCTCAGTTGTATTGGCCAGGACAGCGTGGGGGCATTGCAACTGGTGGCTCAGGG
CAGACCTGTGCCAGACGTTAAGCGCATTGAGTGCAAGCCGCTCTCTGACGCCGAACTGGAGCAGATCATGACCAGCTACC
AGCAAGGGATCCCGCTTGGTATGGTGAGGGAAGAGGACGATTTTCGGATATCCATCGCCGGGGCTCAGGAAAAGACCGCG
TTACTCTACCTCGACAACCGTTGGTGCTTACCGCATGCAGCGACCCCAACCACCCACATTATCAAGCTGCCAATTGGCAA
GATCGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACCCTGATCGCCAAAGCAT
TGGGTCTTCCGGTTCCCCATTGCTTCATCATGCAGGTCGGCAAGGTCAAGGCTCTGGCGGTGGAACGCTTCGATCGGCGC
TACGCCACGGATCGCAGTTGGATCATGCGCCTGCCCCAAGAGGACTTCTGCCAGGTGTTGAATGTACCGTCAGCACGCAA
GTACGAGAGCCATGGTGGACCGGGCATTGCTGACATCATGACGACCCTGCTGGGATCGGCCACGCCGGAGCAGGATCGGT
ACCTGTTTATGAAGTCTCAGGTGTTGTTCTGGCTGCTGGCTGCCACTGATGGCCATGCCAAGAATTTCTCGGTGTTTATC
GAACCTGAAGGGCGTTTCCGGCTTACACCGTTTTACGACATCCTTTCCATGTATCCTGCATTTGGTGGTAAAGGATTACA
TCCCCGTGATGCCAAGTTGGCCATGGGGCTTACTGCAACCAAGGGCAAAAAATACGCGATAGAGCAGATATTTCCTCGCC
ATTTTTATCAAACGGCCAAGGCGATTGGTTTTGAACAAGTGCAGATGGAAAAAATCATCAGCGAACTGACGGATAATCTG
GATGAGGTAATATCAATCGTTCGTCAGCAATTGCCTGATACATTTCCCACTGAGATTGCAGATTCAATTTTGGGTGGACT
CAGTTCGAAAGCGCAACGCTTAAAACGATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11451.29 Da        Isoelectric Point: 6.9796

>AT163087 WP_032938223.1 NZ_CP056238:c4777106-4776789 [Citrobacter freundii]
MSHEVEASSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGEEGNMSGKLKVKFG

Download         Length: 318 bp

>AT163087 NZ_CP072326:2631995-2632249 [Aeromonas caviae]
ATGAAAGTAACCAGCGCCAAGCAACTTAGTGCCTGTCTCAAGGATGCCAGGCTTTCGCAAAAGCTCTCCCAAGGCAAAGT
GGCCGGCAAGGTGGGGATCAGGCAGGACACGGTGTCCAGCTTCGAGCTCAATCCCGAGTCAACCAAGCTGGAGACCTTGT
TCAAGATCCTCGCCGCACTGGAACTCTCCCTCGATATCAGGCCCCGCACCGATCCTGCGGAAAACGCCACGCCTGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0J1MRN0


Antitoxin

Source ID Structure
AlphaFold DB A0A0J1QJH0

References