Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3916685..3917301 Replicon chromosome
Accession NZ_CP056238
Organism Citrobacter freundii strain RHBSTW-00935

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HV330_RS19115 Protein ID WP_181501947.1
Coordinates 3916912..3917301 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag HV330_RS19110 Protein ID WP_045295158.1
Coordinates 3916685..3916915 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV330_RS19095 3912280..3913284 + 1005 WP_117273198.1 IS110-like element IS4321 family transposase -
HV330_RS19100 3913630..3915627 - 1998 WP_181501946.1 choline BCCT transporter BetT -
HV330_RS19105 3915949..3916215 - 267 Protein_3753 IS5/IS1182 family transposase -
HV330_RS19110 3916685..3916915 + 231 WP_045295158.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HV330_RS19115 3916912..3917301 + 390 WP_181501947.1 type II toxin-antitoxin system VapC family toxin Toxin
HV330_RS19120 3917339..3918426 + 1088 WP_088569307.1 IS3 family transposase -
HV330_RS19125 3919223..3920182 + 960 WP_181502595.1 sensor domain-containing diguanylate cyclase -
HV330_RS19130 3920591..3921295 + 705 WP_181501948.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3909681..3943316 33635
- inside IScluster/Tn - - 3909166..3923562 14396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-120)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13411.30 Da        Isoelectric Point: 6.4469

>T163085 WP_181501947.1 NZ_CP056238:3916912-3917301 [Citrobacter freundii]
VNRTYMLDTRFCAFILREQPEAVLTRLEQAVLRGHRIVISAVTWAELSQAARASGPATQALADAFCASLDAVLAWDRAAV
EATTEVKASLAAAGTPIGPNDTAIAGHAIAAGAVLVTRNGNPPEKAVCS

Download         Length: 390 bp

>T163085 NZ_CP072323:85325-85723 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGGTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCTTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8641.84 Da        Isoelectric Point: 6.3000

>AT163085 WP_045295158.1 NZ_CP056238:3916685-3916915 [Citrobacter freundii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGNCIILRPVRPSWSSFAMMGRADPEFMAERGDVVSDKGRSEQ

Download         Length: 231 bp

>AT163085 NZ_CP072323:85098-85325 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCTGCCGGAGAGACATGGGACGAATGGTTCGACGGAA
ACAGTGTCAGCGCTGATTTTATGGATAACAGGGAACAGCCTGGTATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References