Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 276771..277402 Replicon chromosome
Accession NZ_CP056238
Organism Citrobacter freundii strain RHBSTW-00935

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag HV330_RS01285 Protein ID WP_003837806.1
Coordinates 276771..277046 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag HV330_RS01290 Protein ID WP_003837808.1
Coordinates 277043..277402 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV330_RS01275 272822..275569 + 2748 WP_181502065.1 ribosome-associated ATPase/putative transporter RbbA -
HV330_RS01280 275569..276693 + 1125 WP_181502066.1 ABC transporter permease -
HV330_RS01285 276771..277046 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
HV330_RS01290 277043..277402 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV330_RS01295 277515..277916 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
HV330_RS01300 277966..278544 - 579 WP_003837810.1 4'-phosphopantetheinyl transferase AcpT -
HV330_RS01305 278607..279656 - 1050 WP_103848271.1 AI-2E family transporter -
HV330_RS01310 279756..281006 + 1251 WP_146051392.1 MFS transporter -
HV330_RS01315 281010..281567 - 558 WP_003837816.1 DcrB family lipoprotein -
HV330_RS01320 281640..282305 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 261181..305348 44167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T163071 WP_003837806.1 NZ_CP056238:276771-277046 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

>T163071 NZ_CP072322:968321-968428 [Escherichia coli]
ATGACGCTCGCGCAGTTTACCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT163071 WP_003837808.1 NZ_CP056238:277043-277402 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp

>AT163071 NZ_CP072322:c968274-968208 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References