Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 869497..870151 Replicon chromosome
Accession NZ_CP056232
Organism Citrobacter freundii strain RHBSTW-00965

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HV336_RS04195 Protein ID WP_181510287.1
Coordinates 869744..870151 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HV336_RS04190 Protein ID WP_003825514.1
Coordinates 869497..869763 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV336_RS04165 864653..866086 - 1434 WP_181510284.1 6-phospho-beta-glucosidase BglA -
HV336_RS04170 866207..866935 - 729 Protein_817 MurR/RpiR family transcriptional regulator -
HV336_RS04175 866988..867299 + 312 WP_181510285.1 N(4)-acetylcytidine aminohydrolase -
HV336_RS04180 867463..868125 + 663 WP_063940912.1 hemolysin III family protein -
HV336_RS04185 868257..869240 - 984 WP_181510286.1 tRNA-modifying protein YgfZ -
HV336_RS04190 869497..869763 + 267 WP_003825514.1 FAD assembly factor SdhE Antitoxin
HV336_RS04195 869744..870151 + 408 WP_181510287.1 protein YgfX Toxin
HV336_RS04200 870196..870717 - 522 WP_181510288.1 flavodoxin FldB -
HV336_RS04205 870831..871727 + 897 WP_003825519.1 site-specific tyrosine recombinase XerD -
HV336_RS04210 871751..872464 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV336_RS04215 872470..874203 + 1734 WP_181510289.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15921.78 Da        Isoelectric Point: 11.3523

>T163051 WP_181510287.1 NZ_CP056232:869744-870151 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRVILQQAKQK

Download         Length: 408 bp

>T163051 NZ_CP072306:50549-50809 [Acinetobacter baumannii]
ATGAAACGTAATATCGACTTCACCCCTACTGCTTGGGATGATTATTTATATTGGCAAAACCAAGACAAAAAGACGTTAAA
ACGTATTAATGCATTGATTAAAGATTGCCAACGTGAACCATTTAGTGGAATTGGCAAGCCTGAGGGTCTTCTAGGTGATT
TGTCTGGATTCTGGAGCAGACGAATAGATGAAAAAAACCGCTTGGTTTATGCCGTGGATGATGCCGCTATTACAATTATT
TCCTGCAGACACCATTACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10615.14 Da        Isoelectric Point: 5.1700

>AT163051 WP_003825514.1 NZ_CP056232:869497-869763 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADEQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163051 NZ_CP072306:50299-50559 [Acinetobacter baumannii]
ATGAACATACTGACTTACAGCGAGGCGAGAAATAATCTCAAAGAGGTTATAGATCAGGTGATTAATGATGCTGACGTGAC
TGTAATTACTAGACGAGAAGGACAGGATGCAGTTGTAATGGGTTTAGATCATTACAATAGTATGGTTGAAACACTATACC
TACTTTCAAATCCAGCTAATTCGGCTCACTTAGCAAAATCAATCTCCGAGTACCGCGCTAATAAAGCAACTACGAGAGAT
TTAATTGACGATGAAACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References