Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4445996..4446581 Replicon chromosome
Accession NZ_CP056229
Organism Citrobacter freundii strain RHBSTW-00968

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HV337_RS21055 Protein ID WP_181490734.1
Coordinates 4445996..4446310 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HV337_RS21060 Protein ID WP_115259723.1
Coordinates 4446303..4446581 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV337_RS21030 4442110..4443690 + 1581 WP_181490731.1 RNA repair transcriptional activator RtcR -
HV337_RS21035 4443795..4444067 + 273 WP_096758747.1 DUF3811 domain-containing protein -
HV337_RS21040 4444064..4444939 - 876 WP_181490732.1 23S rRNA pseudouridine(2604) synthase RluF -
HV337_RS21045 4445190..4445507 - 318 WP_153880509.1 CcdB family protein -
HV337_RS21050 4445507..4445800 - 294 WP_181490733.1 type II toxin-antitoxin system CcdA family antitoxin -
HV337_RS21055 4445996..4446310 + 315 WP_181490734.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV337_RS21060 4446303..4446581 + 279 WP_115259723.1 putative addiction module antidote protein Antitoxin
HV337_RS21065 4446693..4447382 + 690 WP_115259724.1 dipeptidase PepE -
HV337_RS21070 4447511..4449142 - 1632 WP_117343624.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11983.91 Da        Isoelectric Point: 9.5570

>T163050 WP_181490734.1 NZ_CP056229:4445996-4446310 [Citrobacter freundii]
MEILQTMVFQRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPIGEGISEMRISYGPGYRIYFKQQGCHIIILLCGGDKSS
QANDITMAKMLARSLDYQEIRHHE

Download         Length: 315 bp

>T163050 NZ_CP072306:50299-50559 [Acinetobacter baumannii]
ATGAACATACTGACTTACAGCGAGGCGAGAAATAATCTCAAAGAGGTTATAGATCAGGTGATTAATGATGCTGACGTGAC
TGTAATTACTAGACGAGAAGGACAGGATGCAGTTGTAATGGGTTTAGATCATTACAATAGTATGGTTGAAACACTATACC
TACTTTCAAATCCAGCTAATTCGGCTCACTTAGCAAAATCAATCTCCGAGTACCGCGCTAATAAAGCAACTACGAGAGAT
TTAATTGACGATGAAACGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9863.44 Da        Isoelectric Point: 6.3200

>AT163050 WP_115259723.1 NZ_CP056229:4446303-4446581 [Citrobacter freundii]
MNKLTRYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKALGIELTLKK

Download         Length: 279 bp

>AT163050 NZ_CP072306:50549-50809 [Acinetobacter baumannii]
ATGAAACGTAATATCGACTTCACCCCTACTGCTTGGGATGATTATTTATATTGGCAAAACCAAGACAAAAAGACGTTAAA
ACGTATTAATGCATTGATTAAAGATTGCCAACGTGAACCATTTAGTGGAATTGGCAAGCCTGAGGGTCTTCTAGGTGATT
TGTCTGGATTCTGGAGCAGACGAATAGATGAAAAAAACCGCTTGGTTTATGCCGTGGATGATGCCGCTATTACAATTATT
TCCTGCAGACACCATTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References