Detailed information of TA system TA163044

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 3458622..3459345
• Replicon: chromosome
• Accession: NZ_CP056229
• Organism: Citrobacter freundii strain RHBSTW-00968

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HV337_RS16470
• Protein ID: WP_151996051.1
• Coordinates: 3458622..3458942 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV337_RS16475
• Protein ID: WP_151996052.1
• Coordinates: 3459010..3459345 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV337_RS16455	3454230..3457484	+	3255	WP_181490475.1	ATP-binding protein	-
HV337_RS16460	3457481..3458083	+	603	WP_151996049.1	HNH/ENDO VII family nuclease	-
HV337_RS16465	3458080..3458487	+	408	WP_151996050.1	SMI1/KNR4 family protein	-
HV337_RS16470	3458622..3458942	-	321	WP_151996051.1	TA system toxin CbtA family protein	Toxin
HV337_RS16475	3459010..3459345	-	336	WP_151996052.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV337_RS16480	3459359..3459838	-	480	WP_151996053.1	DNA repair protein RadC	-
HV337_RS16485	3459850..3460314	-	465	WP_151996054.1	antirestriction protein	-
HV337_RS16490	3460503..3463652	-	3150	WP_181490476.1	AIDA repeat-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (10-105)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12168.82 Da
• Isoelectric Point: 6.6417

>T163044 WP_151996051.1 NZ_CP056229:c3458942-3458622 [Citrobacter freundii]
MQISTVSATVSVSSHLSPVQVWRQLLTYLLKHHYGLTLNDTPFHNDTAIQEHIEAEITLSDAVNFLVERYELVRIDRKGF
TWQEQTPFLTATDILRARRATGLMNT

Nucleotide

• Length: 321 bp

>T163044 NZ_CP072300:1666474-1666656 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12586.23 Da
• Isoelectric Point: 5.9511

>AT163044 WP_151996052.1 NZ_CP056229:c3459345-3459010 [Citrobacter freundii]
MNNDAIQTWGLRRDITPCFGSRLVQEGHRLHFLADRAGFTGSFSEVQTLQLDEAFPHFVAHLELMLLSCELNPRYAHCVT
LYRNGLTCEADTLGSYGYVYIAIYPTNQAKD

Nucleotide

• Length: 336 bp

>AT163044 NZ_CP072300:1666749-1667153 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG