Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2401676..2402445 Replicon chromosome
Accession NZ_CP056229
Organism Citrobacter freundii strain RHBSTW-00968

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV337_RS11365 Protein ID WP_181490189.1
Coordinates 2401963..2402445 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV337_RS11360 Protein ID WP_168246960.1
Coordinates 2401676..2401972 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV337_RS11345 2397176..2398363 + 1188 WP_135912045.1 outer membrane protein transport protein -
HV337_RS11350 2398643..2399272 + 630 WP_117342784.1 winged helix-turn-helix transcriptional regulator -
HV337_RS11355 2399581..2401563 + 1983 WP_117342783.1 MBL fold metallo-hydrolase -
HV337_RS11360 2401676..2401972 + 297 WP_168246960.1 DUF1778 domain-containing protein Antitoxin
HV337_RS11365 2401963..2402445 + 483 WP_181490189.1 GNAT family N-acetyltransferase Toxin
HV337_RS11370 2402607..2403398 - 792 WP_181490190.1 SDR family oxidoreductase -
HV337_RS11375 2403547..2404440 + 894 WP_181490191.1 LysR family transcriptional regulator -
HV337_RS11380 2404475..2404759 - 285 Protein_2229 aldo/keto reductase -
HV337_RS11385 2405210..2406259 + 1050 WP_181490192.1 NAD(P)-dependent alcohol dehydrogenase -
HV337_RS11390 2406532..2407323 + 792 WP_181490193.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-146)

Antitoxin

Vibrio phage ICP1, Orf50

(17-91)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17740.35 Da        Isoelectric Point: 8.4643

>T163043 WP_181490189.1 NZ_CP056229:2401963-2402445 [Citrobacter freundii]
MEINVTAPALLTEGHDLQPFNCGNEVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDASTQGHSYGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

>T163043 NZ_CP072300:461604-461993 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCATTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11515.11 Da        Isoelectric Point: 5.8990

>AT163043 WP_168246960.1 NZ_CP056229:2401676-2401972 [Citrobacter freundii]
MEKLMQTSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAP
VQNVEGRQRLMDVKPEWK

Download         Length: 297 bp

>AT163043 NZ_CP072300:461340-461597 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References