Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 731820..732598 Replicon chromosome
Accession NZ_CP056229
Organism Citrobacter freundii strain RHBSTW-00968

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag HV337_RS03645 Protein ID WP_181490967.1
Coordinates 732110..732598 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag HV337_RS03640 Protein ID WP_181490966.1
Coordinates 731820..732113 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV337_RS03620 728075..729172 + 1098 WP_181490963.1 type VI secretion system baseplate subunit TssG -
HV337_RS03625 729147..729680 + 534 WP_181490964.1 type VI secretion system lipoprotein TssJ -
HV337_RS03630 729680..730123 + 444 WP_137362186.1 type VI secretion system baseplate subunit TssE -
HV337_RS03635 730125..731495 + 1371 WP_181490965.1 type VI secretion system ImpA family N-terminal domain-containing protein -
HV337_RS03640 731820..732113 + 294 WP_181490966.1 DUF1778 domain-containing protein Antitoxin
HV337_RS03645 732110..732598 + 489 WP_181490967.1 GNAT family N-acetyltransferase Toxin
HV337_RS03650 732736..733562 - 827 Protein_716 IS3 family transposase -
HV337_RS03660 733913..734620 - 708 WP_096755730.1 DUF554 domain-containing protein -
HV337_RS03665 735089..737224 + 2136 WP_117342646.1 ornithine decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - vipA/tssB 724389..732598 8209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17663.58 Da        Isoelectric Point: 7.2657

>T163032 WP_181490967.1 NZ_CP056229:732110-732598 [Citrobacter freundii]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCDDAKVMAYYSLASSAVTTNTASGRFRRNMPDPI
PVVVLGRLAVDQSLHGRGIGRALIRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLVE
SI

Download         Length: 489 bp

>T163032 NZ_CP072288:2754-3110 [Acinetobacter baumannii]
ATGTGGACAGTCATTACGACAGATCTATTTAATGAATGGCTTGAACAGCAAGATGAATCAACACAAGAGAAGGTTTTAGC
TGCTTTGGTTGTTCTGCAACAACAGGGACCGAGCTTAGGCCGCCCTTTAGTAGATACCGTGTATGACTCTAAATTTACCA
ATATGAAAGAGCTTCGTGTTCAACATCGTGGTAAACCACTCCGAGCTTTTTTTGCATTTGATCCATTACGACAGGCCATT
GTGCTGTGTATTGGTGATAAAGGTGGTAAAAAGCGATTCTATACAGAGATGCTGGCGATTGCAGATCAACAATATGAACT
TCATCTCTCAACATTAGGAGAACAATCTAATGGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10890.53 Da        Isoelectric Point: 6.3782

>AT163032 WP_181490966.1 NZ_CP056229:731820-732113 [Citrobacter freundii]
MPATNSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLALLDQAPAPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT163032 NZ_CP072288:3103-3405 [Acinetobacter baumannii]
ATGGCTAAAACTTTGCAAGAATTATTAGCTAACCGCTCTCCAGAGAGCCAAGCCCGTATTCAAAAAATAGCTGATGAATT
GCTATTAGAAAATCAGCTTTACCTTATTCGTGAAGAACTCGAAATCTCTCAAAAAGAACTGGCTGAAACTTTGGGAATAA
AACAGCCATCACTTTCAGCAATAGAAAATCGTGGCAATGATCTTAAGATCTCAACCATGAAAAAGTATGTTGAAGCAATG
GGAGGGAAGCTCCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGATTCAATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References