163029

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 29201..29778 Replicon plasmid pRHBSTW-00973_4
Accession NZ_CP056225
Organism Klebsiella pneumoniae strain RHBSTW-00973

Toxin (Protein)


Gene name parE Uniprot ID I3W245
Locus tag HV338_RS28070 Protein ID WP_015059150.1
Coordinates 29201..29512 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E3DB50
Locus tag HV338_RS28075 Protein ID WP_014542884.1
Coordinates 29500..29778 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV338_RS28055 24459..27356 - 2898 WP_042111906.1 Tn3-like element Tn5403 family transposase -
HV338_RS28060 27451..28056 + 606 WP_000509966.1 recombinase family protein -
HV338_RS28065 28089..29069 + 981 Protein_29 transposase -
HV338_RS28070 29201..29512 - 312 WP_015059150.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV338_RS28075 29500..29778 - 279 WP_014542884.1 CopG family ribbon-helix-helix protein Antitoxin
HV338_RS28080 30182..30886 - 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
HV338_RS28085 31046..32392 - 1347 WP_077251107.1 ISNCY family transposase -
HV338_RS28090 32674..33108 - 435 WP_001567367.1 cell envelope integrity protein TolA -
HV338_RS28095 33155..33703 - 549 WP_001567366.1 thioredoxin fold domain-containing protein -
HV338_RS28100 34197..34505 + 309 WP_001568014.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..69970 69970
- inside IScluster/Tn - - 17640..32404 14764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11840.74 Da        Isoelectric Point: 9.8620

>T163029 WP_015059150.1 NZ_CP056225:c29512-29201 [Klebsiella pneumoniae]
MPQVIVSALAQRDLQRLQDFLKTKNRLAARKAGEVIIRAIQQLKTQPDMGRPVSLLPLEYQELVIGFGDSGYVMLYRHDR
ETDRIVILTVRHQKEAGYHGLQE

Download         Length: 312 bp

>T163029 NZ_CP072285:1915438-1915620 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10721.74 Da        Isoelectric Point: 4.6216

>AT163029 WP_014542884.1 NZ_CP056225:c29778-29500 [Klebsiella pneumoniae]
MSAATSIRLDDELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLSAEEVEAWIDTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT163029 NZ_CP072285:1915713-1916117 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P6WJV0

Antitoxin

Source ID Structure
AlphaFold DB E3DB50

References