Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 21457..21983 Replicon plasmid pRHBSTW-00973_2
Accession NZ_CP056223
Organism Klebsiella pneumoniae strain RHBSTW-00973

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HV338_RS26600 Protein ID WP_000323025.1
Coordinates 21696..21983 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HV338_RS26595 Protein ID WP_000534858.1
Coordinates 21457..21696 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV338_RS26575 16802..17230 + 429 WP_035897523.1 glutaredoxin-dependent arsenate reductase -
HV338_RS26580 17516..18856 + 1341 WP_000589001.1 ISNCY family transposase -
HV338_RS26585 19499..20071 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
HV338_RS26590 20271..21194 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
HV338_RS26595 21457..21696 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HV338_RS26600 21696..21983 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HV338_RS26605 22131..23474 + 1344 WP_040120121.1 ISNCY family transposase -
HV338_RS26610 23490..23774 - 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin -
HV338_RS26615 23764..24012 - 249 WP_004187025.1 plasmid stabilization protein -
HV338_RS26620 24521..25489 - 969 WP_181479567.1 IS5 family transposase -
HV338_RS26625 25524..25796 + 273 Protein_33 transposase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..176327 176327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T163026 WP_000323025.1 NZ_CP056223:21696-21983 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T163026 NZ_CP072282:c22895-22536 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT163026 WP_000534858.1 NZ_CP056223:21457-21696 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT163026 NZ_CP072282:c22536-22237 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References