163026

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 21457..21983 Replicon plasmid pRHBSTW-00973_2
Accession NZ_CP056223
Organism Klebsiella pneumoniae strain RHBSTW-00973

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HV338_RS26600 Protein ID WP_000323025.1
Coordinates 21696..21983 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HV338_RS26595 Protein ID WP_000534858.1
Coordinates 21457..21696 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV338_RS26575 16802..17230 + 429 WP_035897523.1 glutaredoxin-dependent arsenate reductase -
HV338_RS26580 17516..18856 + 1341 WP_000589001.1 ISNCY family transposase -
HV338_RS26585 19499..20071 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
HV338_RS26590 20271..21194 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
HV338_RS26595 21457..21696 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HV338_RS26600 21696..21983 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HV338_RS26605 22131..23474 + 1344 WP_040120121.1 ISNCY family transposase -
HV338_RS26610 23490..23774 - 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin -
HV338_RS26615 23764..24012 - 249 WP_004187025.1 plasmid stabilization protein -
HV338_RS26620 24521..25489 - 969 WP_181479567.1 IS5 family transposase -
HV338_RS26625 25524..25796 + 273 Protein_33 transposase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..176327 176327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T163026 WP_000323025.1 NZ_CP056223:21696-21983 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T163026 NZ_CP072282:c22895-22536 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT163026 WP_000534858.1 NZ_CP056223:21457-21696 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT163026 NZ_CP072282:c22536-22237 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References