Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4803862..4804378 Replicon chromosome
Accession NZ_CP056222
Organism Klebsiella pneumoniae strain RHBSTW-00973

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag HV338_RS23565 Protein ID WP_004178374.1
Coordinates 4803862..4804146 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HV338_RS23570 Protein ID WP_002886901.1
Coordinates 4804136..4804378 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV338_RS23540 4799337..4799645 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
HV338_RS23545 4799730..4799903 + 174 WP_032414379.1 hypothetical protein -
HV338_RS23550 4799906..4800649 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HV338_RS23555 4801006..4803144 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HV338_RS23560 4803394..4803858 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HV338_RS23565 4803862..4804146 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV338_RS23570 4804136..4804378 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV338_RS23575 4804456..4806366 - 1911 WP_009486549.1 BglG family transcription antiterminator -
HV338_RS23580 4806389..4807543 - 1155 WP_023159544.1 lactonase family protein -
HV338_RS23585 4807610..4808350 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T163023 WP_004178374.1 NZ_CP056222:c4804146-4803862 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T163023 NZ_CP072280:461604-461993 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCATTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT163023 WP_002886901.1 NZ_CP056222:c4804378-4804136 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT163023 NZ_CP072280:461340-461597 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References