163022

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4699896..4700706 Replicon chromosome
Accession NZ_CP056222
Organism Klebsiella pneumoniae strain RHBSTW-00973

Toxin (Protein)


Gene name KacT Uniprot ID A0A7Z7SK09
Locus tag HV338_RS23075 Protein ID WP_040190358.1
Coordinates 4699896..4700405 (-) Length 170 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag HV338_RS23080 Protein ID WP_002887278.1
Coordinates 4700440..4700706 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV338_RS23070 4698727..4699848 + 1122 WP_012737335.1 cupin domain-containing protein -
HV338_RS23075 4699896..4700405 - 510 WP_040190358.1 GNAT family N-acetyltransferase Toxin
HV338_RS23080 4700440..4700706 - 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
HV338_RS23085 4700809..4702242 - 1434 WP_048986922.1 Cu(+)/Ag(+) sensor histidine kinase -
HV338_RS23090 4702232..4702915 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
HV338_RS23095 4703088..4704473 + 1386 WP_048986924.1 efflux transporter outer membrane subunit -
HV338_RS23100 4704491..4704835 + 345 WP_048986926.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(83-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18837.54 Da        Isoelectric Point: 6.2333

>T163022 WP_040190358.1 NZ_CP056222:c4700405-4699896 [Klebsiella pneumoniae]
MIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQQKKIPYQN
APSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNLLFYPTKSI
EQLFTDDES

Download         Length: 510 bp

>T163022 NZ_CP072278:2754-3110 [Acinetobacter baumannii]
ATGTGGACAGTCATTACGACAGATCTATTTAATGAATGGCTTGAACAGCAAGATGAATCAACACAAGAGAAGGTTTTAGC
TGCTTTGGTTGTTCTGCAACAACAGGGACCGAGCTTAGGCCGCCCTTTAGTAGATACCGTGTATGACTCTAAATTTACCA
ATATGAAAGAGCTTCGTGTTCAACATCGTGGTAAACCACTCCGAGCTTTTTTTGCATTTGATCCATTACGACAGGCCATT
GTGCTGTGTATTGGTGATAAAGGTGGTAAAAAGCGATTCTATACAGAGATGCTGGCGATTGCAGATCAACAATATGAACT
TCATCTCTCAACATTAGGAGAACAATCTAATGGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT163022 WP_002887278.1 NZ_CP056222:c4700706-4700440 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT163022 NZ_CP072278:3103-3405 [Acinetobacter baumannii]
ATGGCTAAAACTTTGCAAGAATTATTAGCTAACCGCTCTCCAGAGAGCCAAGCCCGTATTCAAAAAATAGCTGATGAATT
GCTATTAGAAAATCAGCTTTACCTTATTCGTGAAGAACTCGAAATCTCTCAAAAAGAACTGGCTGAAACTTTGGGAATAA
AACAGCCATCACTTTCAGCAATAGAAAATCGTGGCAATGATCTTAAGATCTCAACCATGAAAAAGTATGTTGAAGCAATG
GGAGGGAAGCTCCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGATTCAATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7SK09

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References