Detailed information of TA system TA163019

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2669546..2671134
• Replicon: chromosome
• Accession: NZ_CP056222
• Organism: Klebsiella pneumoniae strain RHBSTW-00973

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2X3IYA0
• Locus tag: HV338_RS13200
• Protein ID: WP_032103210.1
• Coordinates: 2669546..2670868 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HV338_RS13205
• Protein ID: WP_004176198.1
• Coordinates: 2670868..2671134 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV338_RS13185	2664602..2667103	+	2502	WP_048986980.1	fimbrial biogenesis outer membrane usher protein	-
HV338_RS13190	2667091..2668095	+	1005	WP_048986982.1	type 1 fimbrial protein	-
HV338_RS13195	2668237..2669529	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HV338_RS13200	2669546..2670868	-	1323	WP_032103210.1	type II toxin-antitoxin system HipA family toxin	Toxin
HV338_RS13205	2670868..2671134	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HV338_RS13210	2671399..2671725	-	327	WP_048986984.1	hydroxyisourate hydrolase	-
HV338_RS13215	2671722..2672222	-	501	WP_023282573.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HV338_RS13220	2672200..2673579	-	1380	WP_004184021.1	purine permease	-
HV338_RS13225	2673925..2675079	+	1155	WP_048986987.1	FAD-dependent urate hydroxylase HpxO	-
HV338_RS13230	2675060..2675983	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49097.38 Da
• Isoelectric Point: 7.5357

>T163019 WP_032103210.1 NZ_CP056222:c2670868-2669546 [Klebsiella pneumoniae]
MATLTTWMNNVRVGSLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T163019 NZ_CP072275:1666474-1666656 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT163019 WP_004176198.1 NZ_CP056222:c2671134-2670868 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT163019 NZ_CP072275:1666749-1667153 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: A0A2X3IYA0