Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 846225..846882 Replicon chromosome
Accession NZ_CP056222
Organism Klebsiella pneumoniae strain RHBSTW-00973

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HV338_RS04220 Protein ID WP_002916310.1
Coordinates 846472..846882 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HV338_RS04215 Protein ID WP_002916312.1
Coordinates 846225..846491 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV338_RS04190 841381..842814 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HV338_RS04195 842933..843661 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HV338_RS04200 843711..844022 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HV338_RS04205 844186..844845 + 660 WP_002916317.1 hemolysin III family protein -
HV338_RS04210 844996..845979 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HV338_RS04215 846225..846491 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HV338_RS04220 846472..846882 + 411 WP_002916310.1 protein YgfX Toxin
HV338_RS04225 846889..847410 - 522 WP_048986774.1 flavodoxin FldB -
HV338_RS04230 847511..848407 + 897 WP_023284285.1 site-specific tyrosine recombinase XerD -
HV338_RS04235 848430..849143 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV338_RS04240 849149..850882 + 1734 WP_048334395.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T163010 WP_002916310.1 NZ_CP056222:846472-846882 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T163010 NZ_CP072268:c4600699-4600565 [Xanthomonas euvesicatoria pv. alfalfae]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGCGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT163010 WP_002916312.1 NZ_CP056222:846225-846491 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163010 NZ_CP072268:c4600926-4600774 [Xanthomonas euvesicatoria pv. alfalfae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCGACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References