Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 40907..41643 Replicon plasmid pRHBSTW-00982_2
Accession NZ_CP056217
Organism Klebsiella pneumoniae strain RHBSTW-00982

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV343_RS25650 Protein ID WP_074384329.1
Coordinates 41161..41643 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV343_RS25645 Protein ID WP_032415032.1
Coordinates 40907..41173 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV343_RS25610 36751..37113 - 363 WP_004206665.1 arsenite efflux transporter metallochaperone ArsD -
HV343_RS25615 37165..37515 - 351 WP_004206664.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
HV343_RS25620 37873..38121 + 249 WP_004193994.1 hypothetical protein -
HV343_RS25625 38118..39329 + 1212 WP_032415728.1 hypothetical protein -
HV343_RS25630 39463..39954 + 492 WP_004206662.1 hypothetical protein -
HV343_RS25635 40015..40218 + 204 WP_004206661.1 hemolysin expression modulator Hha -
HV343_RS25640 40232..40462 + 231 WP_004206660.1 hypothetical protein -
HV343_RS25645 40907..41173 + 267 WP_032415032.1 DUF1778 domain-containing protein Antitoxin
HV343_RS25650 41161..41643 + 483 WP_074384329.1 GNAT family N-acetyltransferase Toxin
HV343_RS25655 42073..43785 - 1713 WP_038992633.1 ROK family protein -
HV343_RS25660 44068..45084 + 1017 WP_038992636.1 hypothetical protein -
HV343_RS25665 45081..46013 + 933 WP_038992638.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..144961 144961


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-148)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17317.04 Da        Isoelectric Point: 10.0704

>T163008 WP_074384329.1 NZ_CP056217:41161-41643 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGLKSSQTHERTLFLKLP

Download         Length: 483 bp

>T163008 NZ_CP072267:c13122-12790 [Xanthomonas citri pv. glycines]
ATGGAGCGGGGTGATATCTATCTTGTGTCTCTCGATCCTACTTCCGGCCATGAGCAACAGGGCACTCGCCCGGTCCTGAT
TGTGTCGCCGGGACCGTTCAACCGCCTTACCAAAACACCCGTGGTGCTACCGATCACCACGGGTGGCAATTTCGCCCGTA
CGGCAGGTTTCACGGTATCCCTCACGGGGGGAGGCACCAAAACGACCGGAGTCGTGCGCTGCGATCAACCGCGCGCCCTG
GACATTGGATCGCGTAACGGCCGCAAGCTGGAAAGCGTCTCAGCAGCGATCACCGATGAGGTGATGGCTAAGCTGGCGAC
CATACTTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10123.53 Da        Isoelectric Point: 4.5141

>AT163008 WP_032415032.1 NZ_CP056217:40907-41173 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT163008 NZ_CP072267:c13379-13122 [Xanthomonas citri pv. glycines]
ATGCACACGACAAATCTGCGCAAGGTTGGCGGTTCGGTCATGCTCGCGGTTCCGCCTGCGCTGCTCGATGTGCTGCACAT
CGGGGCAGGGGCAAAAGTGGGCTTGGCTGTCGATAACGGCCGCTTGGTAGTCGAGCCACATGCGCGCCCGCGCTACACCC
TCGCCGACCTGCTCGCCCAATGCGATGCGTCAGCCGAGCTGGCTTCCGAAGATCGGGAATGGCTTGACGCCAAGCCTGTT
GGCGGCGAGCTGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References